Review Article

Clinical multiphoton tomography

  1. Karsten König1,2,3,*

Article first published online: 14 JAN 2008

DOI: 10.1002/jbio.200710022

Issue

Journal of Biophotonics

Journal of Biophotonics

Volume 1, Issue 1, pages 13–23, March 2008

Additional Information

How to Cite

König, K. (2008), Clinical multiphoton tomography. J. Biophoton., 1: 13–23. doi: 10.1002/jbio.200710022

Author Information

  1. 1

    Faculty of Mechatronics and Physics, Saarland University, Campus, 66123 Saarbrücken, Germany, www.laser-saarland.de

  2. 2

    Jenlab GmbH, Schillerstrasse 1, 07745 Jena, Germany, www.jenlab.de

  3. 3

    Fraunhofer IBMT, Ensheimer Strasse 48, 66386 St. Ingbert

*Phone: +49 174 313663. Fax: +49 6813023090

Publication History

  1. Issue published online: 4 MAR 2008
  2. Article first published online: 14 JAN 2008
  3. Manuscript Accepted: 21 DEC 2007
  4. Manuscript Revised: 20 DEC 2007
  5. Manuscript Received: 12 NOV 2007

Funded by

  • European Commisssion (MEDPHOT)
  • German Ministry of Education and Research (BMBT, innovation award 2005). Grant Number: 01EZ0331

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Keywords:

  • multiphoton tomography;
  • two-photon;
  • femtosecond laser;
  • melanoma, skin

Abstract

Clinical multiphoton tomography and two-photon microendoscopy provide clinicians and researchers with high-resolution in vivo optical biopsies based on two-photon autofluorescence, second harmonic generation, and fluorescence lifetime imaging. This review reflects state of the art technology and reports on applications in the fields of early stage melanoma detection, skin aging, nanoparticle imaging, tissue engineering, and in situ screening of pharmaceutical and cosmetical products. So far, more than 500 patients and volunteers in Europe, Asia, and Australia have been investigated with these novel molecular imaging tools. (© 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)

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