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Full Article
Toward the integration of cytomics and medicine
Article first published online: 5 JUN 2009
DOI: 10.1002/jbio.200900032
Copyright © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Issue
Journal of Biophotonics
Special Issue: Towards in vivo Flow Cytometry
Volume 2, Issue 8-9, pages 482–493, September 2009
Additional Information
How to Cite
Leif, R. C. (2009), Toward the integration of cytomics and medicine. J. Biophoton., 2: 482–493. doi: 10.1002/jbio.200900032
Publication History
- Issue published online: 9 SEP 2009
- Article first published online: 5 JUN 2009
- Manuscript Accepted: 12 MAY 2009
- Manuscript Revised: 11 MAY 2009
- Manuscript Received: 13 APR 2009
Funded by
- Newport Instruments
- Abstract
- References
- Cited By
Keywords:
- CytometryML;
- series;
- instance;
- ZIP;
- cytometry;
- container;
- schema;
- table of contents;
- metadata;
- standard;
- list-mode
Abstract
The integration of cytomics research and healthcare informatics will facilitate technology transfer and reduce medical costs. The CytometryML prototype of the Advanced Cytometry Standard (ACS) has the benefits of including microscopic image and flow list-mode data, being based on XML and thus is compatible with existing medical and scientific informatics standards, such as HL7, and employing a design based upon the Digital Imaging and Communications in Medicine (DICOM) standard. The reuse of the well tested DICOM model resulted in a great decrease in the design and documentation effort and increased probability of reliability. Schemas for flow cytometers and microscopes have been created. XML schemas for two related types of container (ZIP) files have been specified for a set of measurements. The series and instance containers respectively include the metadata that is constant and the metadata that is specific to an individual or small closely related group of measurements. (© 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)