Review Article

Clinical applications of slide-based cytometry – an update

  1. Andreas O. H. Gerstner1,*,
  2. Wiebke Laffers1,
  3. Attila Tárnok2

Article first published online: 10 AUG 2009

DOI: 10.1002/jbio.200910029

Issue

Journal of Biophotonics

Journal of Biophotonics

Special Issue: Towards in vivo Flow Cytometry

Volume 2, Issue 8-9, pages 463–469, September 2009

Additional Information

How to Cite

Gerstner, A. O. H., Laffers, W. and Tárnok, A. (2009), Clinical applications of slide-based cytometry – an update. J. Biophoton., 2: 463–469. doi: 10.1002/jbio.200910029

Author Information

  1. 1

    Department of Otorhinolaryngology / Head and Neck Surgery, University of Bonn, Sigmund-Freud-Str. 25, 53105 Bonn, Germany

  2. 2

    Department of Pediatric Cardiology, Heart Center, University of Leipzig, Strümpellstr. 39, 04289 Leipzig, Germany

*Tel.: +49-228-28715556, Fax: +49-228-28719161

Publication History

  1. Issue published online: 9 SEP 2009
  2. Article first published online: 10 AUG 2009
  3. Manuscript Accepted: 16 JUL 2009
  4. Manuscript Revised: 3 JUL 2009
  5. Manuscript Received: 31 MAR 2009

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Keywords:

  • slide-based cytometry;
  • hypocellular samples;
  • multiparametric analysis;
  • tissue sections;
  • fine-needle aspirate biopsies;
  • cancer;
  • immunophenotyping;
  • single cell detection;
  • fluorescence;
  • quantitative analysis;
  • DNA;
  • siRNA;
  • leukemia;
  • apoptosis

Abstract

Slide-based cytometric approaches open the possibility to obtain quantitative and objective data from specimens that so far have not been accessible to this kind of analysis. In this review, we will highlight the specific advantages of slide-based cytometry (SBC) and show the applications that have been established for clinical samples. Focuses are cytomic analyses of oncological and hematological samples where the slide-based concept turned out to open new dimensions in understanding underlying cellular networks. We review the recent literature and point out future applications. (© 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)

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