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In vivo optical monitoring of tissue pathologies and diseases with vibrational contrast
Article first published online: 21 OCT 2009
DOI: 10.1002/jbio.200910071
Copyright © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Issue
Journal of Biophotonics
Special Issue: Biophotonics in Regenerative Medicine
Volume 2, Issue 11, pages 632–642, November 2009
Additional Information
How to Cite
Bégin, S., Bélanger, E., Laffray, S., Vallée, R. and Côté, D. (2009), In vivo optical monitoring of tissue pathologies and diseases with vibrational contrast. Journal of Biophotonics, 2: 632–642. doi: 10.1002/jbio.200910071
Publication History
- Issue published online: 21 OCT 2009
- Article first published online: 21 OCT 2009
- Manuscript Accepted: 29 SEP 2009
- Manuscript Revised: 28 SEP 2009
- Manuscript Received: 21 AUG 2009
- Abstract
- References
- Cited By
Keywords:
- medical and biological imaging;
- spectroscopy;
- coherent anti-Stokes Raman scattering;
- nonlinear microscopy;
- three-dimensional microscopy
Abstract
Studies of tissue remodeling require in vivo imaging techniques that are as minimally invasive as possible to avoid microenvironment perturbations. To this end, spontaneous Raman techniques have been used but low signals have limited their application mostly to point spectroscopy measurements. Novel Raman-based techniques such as coherent and stimulated Raman scattering can overcome this limitation. This manuscript discusses imaging and spectroscopy applications with Raman-based contrast for in vivo tissue monitoring, and how these can be combined into spectral imaging. (© 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)