Full Article

Monitoring of glucose permeability in monkey skin in vivo using Optical Coherence Tomography

  1. Mohamad G. Ghosn1,
  2. Narendran Sudheendran2,
  3. Mark Wendt3,
  4. Adrian Glasser3,
  5. Valery V. Tuchin4,5,
  6. Kirill V. Larin1,2,4,*

Article first published online: 12 OCT 2009

DOI: 10.1002/jbio.200910075

Issue

Journal of Biophotonics

Journal of Biophotonics

Special Issue: Biophotonics for Dermatology: Science and Applications

Volume 3, Issue 1-2, pages 25–33, January 2010

Additional Information

How to Cite

Ghosn, M. G., Sudheendran, N., Wendt, M., Glasser, A., Tuchin, V. V. and Larin, K. V. (2010), Monitoring of glucose permeability in monkey skin in vivo using Optical Coherence Tomography. Journal of Biophotonics, 3: 25–33. doi: 10.1002/jbio.200910075

Author Information

  1. 1

    Department of Biomedical Engineering, University of Houston, 4800 Calhoun Rd., N207 Engineering Bldg 1, Houston, Texas 77204-4006, TX USA

  2. 2

    Department of Electrical and Computer Engineering, University of Houston, Houston, TX USA

  3. 3

    College of Optometry, University of Houston, Houston, TX USA

  4. 4

    Institute of Optics and Photonics, Saratov State University, Saratov, Russia

  5. 5

    Institute of Precise Mechanics and Control of RAS, Saratov, Russia

*Phone: (832) 842-8834, Fax: (713) 743-4503

Publication History

  1. Issue published online: 22 DEC 2009
  2. Article first published online: 12 OCT 2009
  3. Manuscript Accepted: 22 SEP 2009
  4. Manuscript Revised: 21 SEP 2009
  5. Manuscript Received: 31 AUG 2009

Funded by

  • NIH. Grant Number: R01 HL095586
  • Office of Naval Research. Grant Number: N000140710943
  • NEI. Grant Number: 1 RO1 EY014651
  • CRDF. Grant Number: RUB1–2932-SR-08
  • Federal Agency of Education of RF. Grant Numbers: 2.1.1/4989, 2.2.1.1/2950, 1.4.09
  • President of the RF. Grant Number: 208.2008.2
  • FP7-ICT-2007–2 PHOTONICS4LIFE. Grant Number: 224014

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

Get PDF (507K)

Keywords:

  • optical coherence tomography;
  • permeability rate;
  • diffusion;
  • skin

Abstract

Topical trans-dermal delivery of drugs has proven to be a promising route for treatment of many dermatological diseases. The aim of this study is to monitor and quantify the permeability rate of glucose solutions in rhesus monkey skin noninvasively in vivo as a primate model for drug diffusion. A time-domain Optical Coherence Tomography (OCT) system was used to image the diffusion of glucose in the skin of anesthetized monkeys for which the permeability rate was calculated. From 5 experiments on 4 different monkeys, the permeability for glucose-20% was found to be (4.41 ± 0.28) 10–6 cm/sec. The results suggest that OCT might be utilized for the noninvasive study of molecular diffusion in the multilayered biological tissues in vivo. (© 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)

Get PDF (507K)