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Keywords:

  • resonant Mie scattering correction;
  • infrared micro-spectral imaging;
  • breast micro-metastasis;
  • hierarchical cluster analysis;
  • extended multiplicative signal correction

Abstract

In this manuscript, we report the application of EMSC to correct infrared micro-spectral data recorded from tissue that describe resonant Mie scattering contributions. Small breast micro-metastases previously undetectable using the raw measured spectra were provided clear contrast from the surrounding tissue after signal correction. The technique also proved transferrable, successfully correcting imaging data sets recorded from multiple patients. It is envisaged more robust methods of supervised analysis can now be constructed to automatically classify and diagnose tissue spectra. (© 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)