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Keywords:

  • optical fibers;
  • fluorescent proteins;
  • neuroscience;
  • ultrafast nonlinear optics

Abstract

Specialty fiber probes are used for in vivo depth-resolved mapping of neuron activity through the optical detection of fluorescent-protein reporters expressed inside the living brain of anesthetized transgenic mice. Supercontinuum radiation produced by highly nonlinear photonic-crystal fibers is employed to demonstrate a simultaneous multicolor interrogation of several biomarkers in a model aqueous solution system, thus suggesting the way toward a multiplex mapping of various types of neuron dynamics inside the living brain. (© 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)