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OCT-guided laser hyperthermia with passively tumor-targeted gold nanoparticles

  1. Marina A. Sirotkina1,2,*,
  2. Vadim V. Elagin1,
  3. Marina V. Shirmanova1,
  4. Marina L. Bugrova1,
  5. Ludmila B. Snopova1,
  6. Vladislav A. Kamensky3,
  7. Victor A. Nadtochenko4,
  8. Nikolay N. Denisov4,
  9. Elena V. Zagaynova1,*

Article first published online: 12 JUL 2010

DOI: 10.1002/jbio.201000061

Issue

Journal of Biophotonics

Journal of Biophotonics

Special Issue: Nanobiophotonics

Volume 3, Issue 10-11, pages 718–727, October 2010

Additional Information

How to Cite

Sirotkina, M. A., Elagin, V. V., Shirmanova, M. V., Bugrova, M. L., Snopova, L. B., Kamensky, V. A., Nadtochenko, V. A., Denisov, N. N. and Zagaynova, E. V. (2010), OCT-guided laser hyperthermia with passively tumor-targeted gold nanoparticles. J. Biophoton., 3: 718–727. doi: 10.1002/jbio.201000061

Author Information

  1. 1

    Nizhny Novgorod State Medical Academy, 603005 Minin Sq., 10/1, Nizhny Novgorod, Russia

  2. 2

    N.I. Lobachevsky State University of Nizhny Novgorod, 603022 Gagarin Ave., 23, Nizhny Novgorod, Russia

  3. 3

    Institute of Applied Physics RAS, 603950 Ulyanov St., 46, Nizhny Novgorod, Russia

  4. 4

    Institute of Problems of Chemical Physics RAS, 142432, Semenov av.1, Chernogolovka, Russia

*Phone: +7 831 465 4113, Fax: +7 831 465 5904

Publication History

  1. Issue published online: 16 SEP 2010
  2. Article first published online: 12 JUL 2010
  3. Manuscript Accepted: 27 JUN 2010
  4. Manuscript Revised: 15 JUN 2010
  5. Manuscript Received: 27 APR 2010

Funded by

  • Federal Agency in Science and Innovations. Grant Numbers: 02.740.11.0713, MD-3018.2009.7
  • RFBR grants. Grant Numbers: 09-02-97072, 09-02-12215, 09-02-00539

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Keywords:

  • laser hyperthermia;
  • OCT;
  • gold nanoparticles;
  • mouse tumor model;
  • apoptosis

Abstract

The goal of this study is the development of a method of local laser hyperthermia with gold nanoparticles under noninvasive optical monitoring of nanoparticle accumulation in tumor tissue in vivo. Bifunctional plasmon resonant nanoparticles that are optimal for OCT diagnostics and laser heating at the wavelength of 810 nm were used in the study. The OCT examination showed that the accumulation of gold nanoparticles in the tumor invading into skin was maximal 4–5 h after intravenous injection. It was demonstrated that nanoparticle accumulation in tumor allowed more local heating and enhanced thermal sensitivity of tumor tissue. Laser hyperthermia that heated tumor up to 44–45 °C at maximum nanoparticle accumulation induced apoptotic death of tumor cells and inhibited tumor growth by 104% on the 5th day after treatment. (© 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)

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