Clinical SERS: are we there yet?

Authors

  • Kiang Wei Kho,

    1. Bio-photonics group, School of Physics, National University of Ireland, Galway, Ireland
    2. National Cancer Centre Singapore, 11 Hospital drive, Singapore 169610, Singapore
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  • Chit Yaw Fu,

    1. Bio-photonics group, School of Physics, National University of Ireland, Galway, Ireland
    2. Agency for Science, Technology, and Research, Singapore Bioimaging Consortium, Biomedical Science Institutes, 11 Biopolis Way, #02-02 Helios, Singapore 138667s, Singapore
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  • U. S. Dinish,

    1. Agency for Science, Technology, and Research, Singapore Bioimaging Consortium, Biomedical Science Institutes, 11 Biopolis Way, #02-02 Helios, Singapore 138667s, Singapore
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  • Malini Olivo

    Corresponding author
    1. Bio-photonics group, School of Physics, National University of Ireland, Galway, Ireland
    2. National Cancer Centre Singapore, 11 Hospital drive, Singapore 169610, Singapore
    3. Agency for Science, Technology, and Research, Singapore Bioimaging Consortium, Biomedical Science Institutes, 11 Biopolis Way, #02-02 Helios, Singapore 138667s, Singapore
    4. Department of Pharmacy, National University of Singapore, 18 Science Drive 4, Singapore 117543, Singapore
    • Phone: +353 (0)91 493595, Fax: +353-91-494584
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Abstract

Surface Enhanced Raman Spectroscopy or SERS has witnessed many successes over the past 3 decades, owing particularly to its simplicity of use as well as its highly-multiplexing capability. This article provides an overview of SERS and its applicability in the field of bio-medicine. We will preview recent developments in SERS substrate designs, and the various sensing technologies that are based on the SERS phenomenon. An overview of the clinical applications of SERS is also included. Finally, we provide an opinion on the future trends of this unique spectroscopic technique. (© 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)

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