SEARCH

SEARCH BY CITATION

Keywords:

  • biophotonics;
  • correlation;
  • flow;
  • microcirculation;
  • microvasculature;
  • optical imaging;
  • optical sectioning;
  • photoacoustic;
  • optical coherence tomography

Abstract

Physics has delivered extraordinary developments in almost every facet of modern life. From the humble thermometer and stethoscope to X-Ray, CT, MRI, ultrasound, PET and radiotherapy, our health has been transformed by these advances yielding both morphological and functional metrics. Recently high resolution label-free imaging of the microcirculation at clinically relevant depths has become available in the research domain. In this paper, we present a comprehensive review on current imaging techniques, state-of-the-art advancements and applications, and general perspectives on the prospects for these modalities in the clinical realm. (© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)