Noninvasive blood glucose monitoring during oral intake of different sugars with optical coherence tomography in human subjects

Authors

  • Yuqing Zhang,

    1. MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, Guangdong Province, China
    Search for more papers by this author
  • Huajiang Wei,

    Corresponding author
    1. MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, Guangdong Province, China
    • Phone: (86) 020-85211436, Fax: (86) 020-85216052
    Search for more papers by this author
  • Hongqin Yang,

    1. Key Laboratory of Optoelectronic Science and Technology for Medicine of Ministry of Education of China, Fujian Normal University, Fuzhou 350007, Fujian, China
    Search for more papers by this author
  • Yonghong He,

    1. Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, Guangdong, China
    Search for more papers by this author
  • Guoyong Wu,

    1. Department of Surgery, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, Guangdong Province, China
    Search for more papers by this author
  • Shusen Xie,

    1. Key Laboratory of Optoelectronic Science and Technology for Medicine of Ministry of Education of China, Fujian Normal University, Fuzhou 350007, Fujian, China
    Search for more papers by this author
  • Zhenguo Zhu,

    1. MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, Guangdong Province, China
    Search for more papers by this author
  • Ruoyu He

    1. MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, Guangdong Province, China
    Search for more papers by this author

Abstract

The potential of OCT applied to noninvasive blood glucose monitoring has attracted significant efforts. In this work we investigated the feasibility of OCT in monitoring blood glucose during oral intake of different sugars in humans. Five groups of experiments were performed, in which different sugars were used. The OCT signal slope (OCTSS) changed with variation of blood glucose concentration (BGC). A good correlation between OCTSS and BGC was observed in these experiments. The averaged correlation coefficients R between OCTSS and BGC are 0.900, 0.836, 0.895 and 0.884, corresponding to oral administration of glucose, fructose, sucrose and mixed sugar, respectively. Our studies demonstrated the capability and accuracy of the OCT system in monitoring BGC noninvasively and it could become a powerful tool in daily blood glucose monitoring for patients. (© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)

Ancillary