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Investigation of the human tympanic membrane oscillation ex vivo by Doppler optical coherence tomography

  1. Anke Burkhardt1,†,*,
  2. Lars Kirsten1,†,
  3. Matthias Bornitz2,
  4. Thomas Zahnert2,
  5. Edmund Koch1

Article first published online: 7 DEC 2012

DOI: 10.1002/jbio.201200186

Additional Information

How to Cite

Burkhardt, A., Kirsten, L., Bornitz, M., Zahnert, T. and Koch, E. (2012), Investigation of the human tympanic membrane oscillation ex vivo by Doppler optical coherence tomography. J. Biophoton.. doi: 10.1002/jbio.201200186

Author Information

  1. 1

    Dresden University of Technology, Faculty of Medicine Carl Gustav Carus, Department Clinical Sensoring and Monitoring, Fetscherstraße 74, 01307 Dresden, Germany

  2. 2

    Dresden University of Technology, Faculty of Medicine Carl Gustav Carus, Clinic of Otorhinolaryngology, Fetscherstraße 74, 01307 Dresden, Germany

  1. †

    Both authors contributed equally to this paper.

*Phone: +49 351 458 6135, Fax: +49 351 458 6325

  1. †

    Both authors contributed equally to this paper.

Publication History

  1. Article first published online: 7 DEC 2012
  2. Manuscript Accepted: 20 NOV 2012
  3. Manuscript Revised: 23 OCT 2012
  4. Manuscript Received: 14 SEP 2012

Funded by

  • German Federal Ministry of Education and Research (BMBF) within the joint project “fundamental research Energy 2020+”, project number 02NUK010C and 02NUK010l
  • European Union (ESF) and the Free State of Saxony (project 080937940)
  • European Social Fund and Micro-Epsilon Optronic GmbH, Germany

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Keywords:

  • tympanic membrane;
  • optical coherence tomography;
  • vibration;
  • Doppler

Abstract

Investigations of the tympanic membrane (TM) can have an important impact on understanding the sound conduction in the ear and can therefore support the diagnosis and treatment of diseases in the middle ear. High-speed Doppler optical coherence tomography (OCT) has the potential to describe the oscillatory behaviour of the TM surface in a phase-sensitive manner and additionally allows acquiring a three-dimensional image of the underlying structure. With repeated sound stimuli from 0.4 kHz to 6.4 kHz, the whole TM can be set in vibration and the spatially resolved frequency response functions (FRFs) of the tympanic membrane can be recorded. Typical points, such as the umbo or the manubrium of malleus, can be studied separately as well as the TM surface with all stationary and wave-like vibrations. Thus, the OCT methodology can be a promising technique to distinguish between normal and pathological TMs and support the differentiation between ossicular and membrane diseases. (© 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)

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