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Estimating the risk of squamous cell cancer induction in skin following nonlinear optical imaging

  1. Giju Thomas1,*,
  2. Oleg Nadiarnykh2,
  3. Johan van Voskuilen2,
  4. Christopher L. Hoy1,
  5. Hans C. Gerritsen2,
  6. Henricus J. C. M. Sterenborg1

Article first published online: 8 FEB 2013

DOI: 10.1002/jbio.201200207

Additional Information

How to Cite

Thomas, G., Nadiarnykh, O., van Voskuilen, J., Hoy, C. L., Gerritsen, H. C. and Sterenborg, H. J. C. M. (2013), Estimating the risk of squamous cell cancer induction in skin following nonlinear optical imaging. J. Biophoton.. doi: 10.1002/jbio.201200207

Author Information

  1. 1

    Centre for Optical Diagnostics and Therapy, Erasmus Medical Centre, Post Box 2040, 3000 CA, Rotterdam, The Netherlands

  2. 2

    Department of Molecular Biophysics, Utrecht University, 3508 TA, Utrecht, The Netherlands

*Phone: 0031-10-7032132, Fax: 0031-10-7032141

Publication History

  1. Article first published online: 8 FEB 2013
  2. Manuscript Accepted: 16 JAN 2013
  3. Manuscript Revised: 31 DEC 2012
  4. Manuscript Received: 30 OCT 2012

Funded by

  • Dutch Technology Foundation (STW). Grant Number: UU 10320

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Keywords:

  • nonlinear imaging;
  • cyclic pyrimidine dimers;
  • carcinogenesis;
  • relative risk;
  • UV radiation;
  • biological hazard;
  • femto-second pulses

Abstract

High power femto-second (fs) laser pulses used for in-vivo nonlinear optical (NLO) imaging can form cyclobutane pyrimidine dimers (CPD) in DNA, which may lead to carcinogenesis via subsequent mutations. Since UV radiation from routine sun exposure is the primary source of CPD lesions, we evaluated the risk of CPD-related squamous cell carcinoma (SCC) in human skin due to NLO imaging relative to that from sun exposure. We developed a unique cancer risk model expanding previously published estimation of risk from exposure to continuous wave (CW) laser. This new model showed that the increase in CPD-related SCC in skin from NLO imaging is negligible above that due to regular sun exposure. (© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)

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