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Abstract

The cover art shows simultaneous multi-site two-photon photostimulation along the three-dimensional (3D) dendritic arbor of a layer II neocortical neuron. Three foci positioned at different planes are shown at which glutamate (Glu) is locally released from its chemical cage (MNI) within each focus. Binding of this neurotransmitter to ionotropic ligand-gated ion-channels causes an excitatory post-synaptic current flow of Na+/Ca++ into the neuron. Photostimulating synapses at multiple 3D sites could elucidate how neurons process information. (Picture: M. A. Go et al., pp. 101–118 in this issue)