Effect of photodynamic therapy on the skin using the ultrashort laser ablation

Authors

  • Gustavo Nicolodelli,

    Corresponding author
    1. Physics Institute of Sao Carlos IFSC, University of Sao Paulo, Biophotonics Laboratory, Sao Carlos-SP, Brazil
    • Phone: +55 016 21072800, Fax: +55 016 21072902===

    Search for more papers by this author
  • Dora Patricia Ramírez Angarita,

    1. Physics Institute of Sao Carlos IFSC, University of Sao Paulo, Biophotonics Laboratory, Sao Carlos-SP, Brazil
    2. Biotechnology Program PPGBiotec, Federal University of Sao Carlos UFSCAr, Sao Carlos-SP, Brazil
    Search for more papers by this author
  • Natalia Mayumi Inada,

    1. Physics Institute of Sao Carlos IFSC, University of Sao Paulo, Biophotonics Laboratory, Sao Carlos-SP, Brazil
    Search for more papers by this author
  • Luis Fernando Tirapelli,

    1. Department of Surgery and Anatomy, Ribeirao Preto Medical School FMUSP-RP, University of Sao Paulo, Ribeirao Preto-SP, Brazil
    Search for more papers by this author
  • Vanderlei Salvador Bagnato

    1. Physics Institute of Sao Carlos IFSC, University of Sao Paulo, Biophotonics Laboratory, Sao Carlos-SP, Brazil
    Search for more papers by this author

Abstract

Photodynamic Therapy (PDT) with 5-aminolevulinic acid (ALA) is known to be limited for applications in tumours of large volume mainly due to the limited penetration of topical photosensitization. The results show that micro-holes created using a femtosecond laser before PDT significantly increased the depth of PDT effect in the healthy tissue. The combination of ultrashort laser ablation technique with PDT showed an important scientific breakthrough related to transportation and delivery of drugs into the deeper regions of the tissue. (© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)

Ancillary