Laser exposure of gold nanorods can induce intracellular calcium transients

Authors

  • Chiara Paviolo,

    1. Biotactical Engineering, Industrial Research Institute Swinburne, Faculty of Engineering and Industrial Science, Swinburne University of Technology, Hawthorn, PO Box 218, Victoria 3122, Australia
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  • John W. Haycock,

    1. Department of Materials Science & Engineering, Kroto Research Institute, University of Sheffield, Sheffield, S3 7HQ, UK
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  • Peter J. Cadusch,

    1. Biotactical Engineering, Industrial Research Institute Swinburne, Faculty of Engineering and Industrial Science, Swinburne University of Technology, Hawthorn, PO Box 218, Victoria 3122, Australia
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  • Sally L. McArthur,

    1. Biotactical Engineering, Industrial Research Institute Swinburne, Faculty of Engineering and Industrial Science, Swinburne University of Technology, Hawthorn, PO Box 218, Victoria 3122, Australia
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  • Paul R. Stoddart

    Corresponding author
    1. Biotactical Engineering, Industrial Research Institute Swinburne, Faculty of Engineering and Industrial Science, Swinburne University of Technology, Hawthorn, PO Box 218, Victoria 3122, Australia
    • Phone: +61 3 9214 5839, Fax: +61 3 9214 5050

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Abstract

Uncoated and poly(styrene sulphonate) (PSS)-coated gold nanorods were taken up by NG108-15 neuronal cells. Exposure to 780 nm laser light at the plasmon resonance wavelength of the gold nanorods was found to induce intracellular Ca2+ transients. The higher Ca2+ peaks were observed at lower laser doses, with the highest levels obtained at a radiant exposure of 0.33 J/cm2. In contrast, the cells without nanoparticles showed a consistently small response, independent of the laser dose. These initial results open up new opportunities for peripheral nerve regeneration treatments and for more efficient optical stimulation techniques. (© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)

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