Novel method for early signs of clinical shock detection by monitoring blood capillary/vessel spatial pattern

Authors

  • Rajesh Kanawade,

    Corresponding author
    1. Clinical Photonics Lab., Erlangen Graduate School in Advanced Optical Technologies SAOT, Friedrich-Alexander-Universität Erlangen-Nürnberg, Paul-Gordan-Straße 6, 91052 Erlangen, Germany
    2. Institute of Photonic Technologies, Friedrich-Alexander-Universität Erlangen-Nürnberg, Paul-Gordan-Straße 3, 91052 Erlangen, Germany
    • Phone: +49 9131 8525848, Fax: +49 9131 8525851

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  • Florian Klämpfl,

    1. Institute of Photonic Technologies, Friedrich-Alexander-Universität Erlangen-Nürnberg, Paul-Gordan-Straße 3, 91052 Erlangen, Germany
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  • Max Riemann,

    1. Department of Oral and Maxillofacial Surgery, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Glück-Straße 11, 91054 Erlangen, Germany
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  • Christian Knipfer,

    1. Department of Oral and Maxillofacial Surgery, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Glück-Straße 11, 91054 Erlangen, Germany
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  • Katja Tangermann-Gerk,

    1. Bayerisches Laserzentrum GmbH, Konrad-Zuse-Straße 2–6, 91052 Erlangen, Germany
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  • Michael Schmidt,

    1. Clinical Photonics Lab., Erlangen Graduate School in Advanced Optical Technologies SAOT, Friedrich-Alexander-Universität Erlangen-Nürnberg, Paul-Gordan-Straße 6, 91052 Erlangen, Germany
    2. Institute of Photonic Technologies, Friedrich-Alexander-Universität Erlangen-Nürnberg, Paul-Gordan-Straße 3, 91052 Erlangen, Germany
    3. Bayerisches Laserzentrum GmbH, Konrad-Zuse-Straße 2–6, 91052 Erlangen, Germany
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  • Florian Stelzle

    1. Clinical Photonics Lab., Erlangen Graduate School in Advanced Optical Technologies SAOT, Friedrich-Alexander-Universität Erlangen-Nürnberg, Paul-Gordan-Straße 6, 91052 Erlangen, Germany
    2. Department of Oral and Maxillofacial Surgery, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Glück-Straße 11, 91054 Erlangen, Germany
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Abstract

The ability to monitor capillary/vessel spatial patterns and local blood volume fractions is critical in clinical shock detection and its prevention in Intensive Care Units (ICU). Although the causes of shock might be different, the basic abnormalities in pathophysiological changes are the same. To detect these changes, we have developed a novel method based on both spectrally and spatially resolved diffuse reflectance spectra. The preliminary study has shown that this method can monitor the spatial distribution of capillary/vessel spatial patterns through local blood volume fractions of reduced hemoglobin and oxyhemoglobin. This method can be used as a real-time and non-invasive tool for the monitoring of shock development and feedback on the therapeutic intervention. (© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)

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