Tissue repair strength using chitosan adhesives with different physical-chemical characteristics

Authors

  • Matthew J. Barton,

    1. School of Medicine, University of Western Sydney, Locked Bag 1797 Penrith, NSW, 2751, Australia
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  • John W. Morley,

    1. School of Medicine, University of Western Sydney, Locked Bag 1797 Penrith, NSW, 2751, Australia
    2. The Bioelectronics and Neuroscience BENS Research Group, MARCS Institute, University of Western Sydney Locked Bag 1797, Penrith NSW 2751 Australia
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  • David A. Mahns,

    1. School of Medicine, University of Western Sydney, Locked Bag 1797 Penrith, NSW, 2751, Australia
    2. The Bioelectronics and Neuroscience BENS Research Group, MARCS Institute, University of Western Sydney Locked Bag 1797, Penrith NSW 2751 Australia
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  • Damia Mawad,

    1. Department of Materials, Department of Bioengineering and Institute for Biomedical Engineering, Imperial College London, Exhibition Road, London SW7 2AZ, UK
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  • Richard Wuhrer,

    1. Advanced Materials Characterisation Facility, University of Western Sydney, Locked Bag 1797 Penrith, NSW, 2751, Australia.
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  • David Fania,

    1. School of Science and Health, University of Western Sydney, Locked Bag 1797 Penrith, NSW, 2751, Australia
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  • Samuel J. Frost,

    1. School of Science and Health, University of Western Sydney, Locked Bag 1797 Penrith, NSW, 2751, Australia
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  • Christian Loebbe,

    1. Scitech Pty Ltd, Preston, Victoria, 3072 Australia
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  • Antonio Lauto

    Corresponding author
    1. School of Medicine, University of Western Sydney, Locked Bag 1797 Penrith, NSW, 2751, Australia
    2. The Bioelectronics and Neuroscience BENS Research Group, MARCS Institute, University of Western Sydney Locked Bag 1797, Penrith NSW 2751 Australia
    • Phone: +61 2 4620. Fax: +61 2 4620 3891

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Abstract

A range of chitosan–based biomaterials have recently been used to perform sutureless, laser-activated tissue repair. Laser-activation has the advantage of bonding to tissue through a non-contact, aseptic mechanism. Chitosan adhesive films have also been shown to adhere to sheep intestine strongly without any chemical modification to chitosan. In this study, we continue to investigate chitosan adhesive films and explore the impact on the tissue repair strength and tensile strength characteristics of four types of adhesive film based on chitosan with different molecular weight and degree of deacetylation. Results showed that adhesives based on chitosan with medium molecular weight achieved the highest bonding strength, tensile strength and E-modulus when compared to the other adhesives. (© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)

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