Influence of sun exposure on the cutaneous collagen/elastin fibers and carotenoids: negative effects can be reduced by application of sunscreen

Authors

  • Maxim E. Darvin,

    Corresponding author
    1. Charité – Universitätsmedizin Berlin, Department of Dermatology, Venerology and Allergology, Center of Experimental and Applied Cutaneous Physiology CCP, Berlin, Germany
    • Phone: +49 30 450 518 208, Fax: +49 30 450 518 918===

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  • Heike Richter,

    1. Charité – Universitätsmedizin Berlin, Department of Dermatology, Venerology and Allergology, Center of Experimental and Applied Cutaneous Physiology CCP, Berlin, Germany
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  • Sebastian Ahlberg,

    1. Charité – Universitätsmedizin Berlin, Department of Dermatology, Venerology and Allergology, Center of Experimental and Applied Cutaneous Physiology CCP, Berlin, Germany
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  • Stefan F. Haag,

    1. Charité – Universitätsmedizin Berlin, Department of Dermatology, Venerology and Allergology, Center of Experimental and Applied Cutaneous Physiology CCP, Berlin, Germany
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  • Martina C. Meinke,

    1. Charité – Universitätsmedizin Berlin, Department of Dermatology, Venerology and Allergology, Center of Experimental and Applied Cutaneous Physiology CCP, Berlin, Germany
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  • Delphine Le Quintrec,

    1. COTY LANCASTER S.A.M., R&D Center, Monaco
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  • Olivier Doucet,

    1. COTY LANCASTER S.A.M., R&D Center, Monaco
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  • Jürgen Lademann

    1. Charité – Universitätsmedizin Berlin, Department of Dermatology, Venerology and Allergology, Center of Experimental and Applied Cutaneous Physiology CCP, Berlin, Germany
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Abstract

Resonance Raman spectroscopy and multi-photon tomography were used in vivo to analyse the influence of sun exposure on the cutaneous carotenoids and collagen/elastin fibers. Comparing Berlin (low sun exposure) and Monegasque (high sun exposure) volunteers, it could be demonstrated that extended sun exposure significantly reduces the cutaneous carotenoids and collagen/elastin concentration (p < 0.05). The tendency towards correlation (R2 = 0.41) between the dermal collagen/elastin (SAAID) and carotenoids confirms the important role of antioxidants in the protection against sun-induced negative effects. The application of sunscreen was shown to be effective, protecting cutaneous carotenoids and collagen/elastin from being damaged subsequent to sun exposure. (© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)

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