In vivo study of endometriosis in mice by photoacoustic microscopy

Authors

  • Yichen Ding,

    1. Department of Biomedical Engineering, College of Engineering, Peking University, Beijing, China
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  • Mingzhu Zhang,

    1. Department of Anesthesiology, Cancer Institute &Hospital, Beijing 100021, China
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  • Jinghe Lang,

    1. Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, China
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  • Jinhua Leng,

    1. Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, China
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  • Qiushi Ren,

    1. Department of Biomedical Engineering, College of Engineering, Peking University, Beijing, China
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  • Jie Yang,

    Corresponding author
    1. Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, China
    • Department of Biomedical Engineering, College of Engineering, Peking University, No. 5 Yiheyuan Road, Beijing 100871, China

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  • Changhui Li

    Corresponding author
    1. Department of Biomedical Engineering, College of Engineering, Peking University, Beijing, China
    • Department of Biomedical Engineering, College of Engineering, Peking University, No. 5 Yiheyuan Road, Beijing 100871, China

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Abstract

Endometriosis (EM) impacts the healthcare and the quality of life for women of reproductive age. However, there is no reliable noninvasive diagnosis method for either animal study or clinical use. In this work, a novel imaging method, photoacoustic microscopy (PAM) was employed to study the EM on the mouse model. Our results demonstrated the PAM noninvasively provided the high contrast and 3D imaging of subcutaneously implanted EM tissue in the nude mouse in vivo. The statistical study also indicated PAM had high sensitivity and specificity in the diagnosis of EM in this animal study. In addition, we also discussed the potential clinical application for PAM in the diagnosis of EM. (© 2014 WILEY-VCH Verlag GmbH &Co. KGaA, Weinheim)

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