In vivo multimodal microscopy is used for detecting the contribution of bone-marrow-derived cells in skin regeneration. The article by Graf et al. demonstrates the use of a novel microscope capable of generating co-registered multimodal images based on optical coherence tomography (grey), microvasculature phase-variance imaging (red), second harmonic generation (blue), and two-photon-excited fluorescence (green) from GFP-expressing bonemarrow-derived cells.
(Picture: B. W. Graf et al., pp. 96–102 in this issue)