Paper presented at Second Materials Engineering and Sciences Conference at the February, 1970, National Meeting of the American Institute of Chemical Engineers, Atlanta, Georgia.
Potential of ceramic materials as permanently implantable skeletal prostheses†
Article first published online: 13 SEP 2004
Copyright © 1970 John Wiley & Sons, Inc.
Journal of Biomedical Materials Research
Volume 4, Issue 3, pages 433–456, September 1970
How to Cite
Hulbert, S. F., Young, F. A., Mathews, R. S., Klawitter, J. J., Talbert, C. D. and Stelling, F. H. (1970), Potential of ceramic materials as permanently implantable skeletal prostheses. J. Biomed. Mater. Res., 4: 433–456. doi: 10.1002/jbm.820040309
- Issue published online: 13 SEP 2004
- Article first published online: 13 SEP 2004
- Manuscript Received: 24 DEC 1969
The feasibility of the use of porous ceramic materials in the permanent repair of skeletal defects was studied from the standpoint of physiological compatibility and in growth of natural bone. High-fired calcium aluminate samples in the form of quarter-inch diameter cylindrical pellets containing interconnecting porous networks were implanted in vivo into canine femurs for 4-, 11-, and 22-week periods. The implants had 65% porosity with pore size falling within one of five distinct ranges from less than 45 μ to about 200 μ in diameter.
Thin sections were prepared by grinding (poly) methyl methacrylate-mounted cross sections of the femurs containing the implanted ceramic samples and adjacent soft tissues. Tissue-prosthetic compatibility was determined using standard histological thin section procedures, electron microbeam probe examinations, autoradiographic techniques, microfadiographic techniques, microchemistry techniques, and ultra-violet fluorescent techniques. Optical microscopic evaluations of each section showed the ceramic samples to be bound lightly by natural bone and gave no detectable signs of tissue incompatibility. Minimum pore size for significant ingrowth of natural bone was indicated to be between 75 and 100 μ.