Presented at the AIME Symposium on Artificial Organs, Symposium on Cardiovascular, Implantable and Dental Prosthesis, October 20, 1971, Detroit, Michigan.
Artificial skin I. Preparation and properties of pluronic F-127 gels for treatment of burns†
Article first published online: 13 SEP 2004
Copyright © 1972 John Wiley & Sons, Inc.
Journal of Biomedical Materials Research
Volume 6, Issue 6, pages 571–582, November 1972
How to Cite
Schmolka, I. R. (1972), Artificial skin I. Preparation and properties of pluronic F-127 gels for treatment of burns. J. Biomed. Mater. Res., 6: 571–582. doi: 10.1002/jbm.820060609
- Issue published online: 13 SEP 2004
- Article first published online: 13 SEP 2004
- Manuscript Received: 15 FEB 1972
The preparation of block polymer surface-active agents derived solely from propylene oxide and ethylene oxide is described. The physical properties of a nonionic surfactant of 12,500 molecular weight, Pluronic F-127, are presented. The toxicity data of the polymeric series is reviewed. The preparation of cold aqueous solutions of the F-127 solution, to which silver salts and other medicaments are then added, is described. By raising the temperature, these fluid liquids are then converted to strong “ringing” gels or viscous ointments which are suitable for application to a burn wound or abraded skin area. The factors involved in altering the yield strength of the gel are presented.