Regulation of drug release from polymer matrices by oscillating magnetic fields
Version of Record online: 13 SEP 2004
Copyright © 1985 John Wiley & Sons, Inc.
Journal of Biomedical Materials Research
Volume 19, Issue 1, pages 67–83, January 1985
How to Cite
Edelman, E. R., Kost, J., Bobeck, H. and Langer, R. (1985), Regulation of drug release from polymer matrices by oscillating magnetic fields. J. Biomed. Mater. Res., 19: 67–83. doi: 10.1002/jbm.820190107
- Issue online: 13 SEP 2004
- Version of Record online: 13 SEP 2004
- Manuscript Accepted: JUL 1984
- Manuscript Received: MAY 1984
The reproducible regulation of release of a macromolecule (bovine serum albumin) from biocompatible polymer systems has been demonstrated. Small magnetic spheres or cylindrical magnets were embedded within the polymer matrix which was then subjected to an oscillating magnetic field. In this fashion baseline release rates could be increased 5- to 10-fold with 5–10% standard error. Parameters critical to the regulation of this release included the position, orientation, and magnetic strength of the embedded objects and the amplitude and frequency of the applied magnetic field. Scanning electronmicrographs of the polymer matrix surface reveal that a gap, approximately 100/μm wide, is formed between the embedded object and adjacent polymer material after repeated exposure to an oscillating magnetic field.