Reduced thrombogenicity of polymers having phospholipid polar groups
Version of Record online: 13 SEP 2004
Copyright © 1990 John Wiley & Sons, Inc.
Journal of Biomedical Materials Research
Volume 24, Issue 8, pages 1069–1077, August 1990
How to Cite
Ishihara, K., Aragaki, R., Ueda, T., Watenabe, A. and Nakabayashi, N. (1990), Reduced thrombogenicity of polymers having phospholipid polar groups. J. Biomed. Mater. Res., 24: 1069–1077. doi: 10.1002/jbm.820240809
- Issue online: 13 SEP 2004
- Version of Record online: 13 SEP 2004
- Manuscript Accepted: 21 FEB 1990
- Manuscript Received: 1 JUN 1989
The thrombogenicity of polymers having a phospholipid polar group, poly(2-methacryloyloxyethyl phosphorylcholine (MPC)-co-n-butyl methacrylate (BMA)), was evaluated by a microsphere-column method with attention to the activation and adhesion of platelets on the polymer surface. When citrated platelet-rich plasma (PRP) contacted with the polymers, a large number of platelets adhered and aggregated on poly(BMA). The number of adherent platelets decreased and deformation and aggregation were suppressed with increasing MPC composition. The same tendency was noted when Ca2+-re-added PRP came in contact with the polymers. In the case of poly(MPC-co-BMA) with 0.320 mole fraction of MPC, activation of platelets and formation of fibrin were completely suppressed. Therefore, MPC moieties in the polymer play an important role in the reduction of thrombogenicity of the polymer.