Determining the degree of cortical bone asymmetry in bilateral, nonpathological, human femur pairs

  1. Teri G. Rosenbaum1,2,3,4,
  2. Tracy Hamblin1,3,
  3. Roy D. Bloebaum1,2,*

Article first published online: 3 NOV 2005

DOI: 10.1002/jbm.a.30568

Issue

Journal of Biomedical Materials Research Part A

Journal of Biomedical Materials Research Part A

Volume 76A, Issue 3, pages 450–455, 1 March 2006

Additional Information

How to Cite

Rosenbaum, T. G., Hamblin, T. and Bloebaum, R. D. (2006), Determining the degree of cortical bone asymmetry in bilateral, nonpathological, human femur pairs. Journal of Biomedical Materials Research Part A, 76A: 450–455. doi: 10.1002/jbm.a.30568

Author Information

  1. 1

    Bone & Joint Research Lab (151F), SLC VA Health Care System, 500 Foothill Blvd., Salt Lake City, UT 84148

  2. 2

    Department of Orthopedics, University of Utah School of Medicine, UT

  3. 3

    Department of Bioengineering, University of Utah, UT

  4. 4

    Veterans Affairs Pre-Doctoral Associated Health Rehabilitation Research Fellowship Program, Office of Academic Affiliations, Washington, DC

*Bone & Joint Research Lab (151F), SLC VA Health Care System, 500 Foothill Blvd., Salt Lake City, UT 84148

Publication History

  1. Issue published online: 18 JAN 2006
  2. Article first published online: 3 NOV 2005
  3. Manuscript Accepted: 2 AUG 2005
  4. Manuscript Revised: 26 JUL 2005
  5. Manuscript Received: 31 JAN 2005

Funded by

  • Department VA SLC HCS, Department of VA Pre-Doctoral Associated Health Rehabilitation Fellowship Program, and the Department of Orthopedics, University of Utah

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Keywords:

  • geometry;
  • cortical bone;
  • asymmetry;
  • implant;
  • bone adaptation

Abstract

When testing the effects of a femoral component on cortical bone following total hip arthroplasty, the patient's implanted femur is often compared with his/her contralateral nonimplanted femur, with differences attributed to the femoral component. However, if normal anatomical differences exist between bilateral femurs, they need to be quantified in order to validate whether the differences between implanted and nonimplanted bilateral femurs are due to the implant or possibility due to intrinsic differences before implantation. This study quantified the geometric properties of cortical bone shape between seven pairs of bilateral, cadaveric, human femurs. The null hypothesis tested stated that the bilateral femurs would not be significantly different in cortical bone geometry. Digitized images of cortical bone cross-sections taken at percent biomechanical lengths (levels 1–8) were used to calculate bone geometry measurements. The paired t-test showed that the only significant difference was in the location of principal axes at the most proximal location, level 1 (p = 0.015). All other measurements and levels were not significant with percent differences less than 6.6%. In conclusion, the data supports attributing cortical bone shape differences between implanted and contralateral nonimplanted femurs in levels 2–8 to the presence of the implant when the significant differences are greater than 6.6%. © 2005 Wiley Periodicals, Inc. J Biomed Mater Res, 2006

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