Biomembrane mimetic polymer poly (2-methacryloyloxyethyl phosphorylcholine-co-n-butyl methacrylate) at the interface of polyurethane surfaces

  1. I. Lee1,2,*,
  2. K. Kobayashi2,
  3. H.Y. Sun1,
  4. S. Takatani2,
  5. L.G. Zhong1

Article first published online: 12 FEB 2007

DOI: 10.1002/jbm.a.30951

Issue

Journal of Biomedical Materials Research Part A

Journal of Biomedical Materials Research Part A

Volume 82A, Issue 2, pages 316–322, August 2007

Additional Information

How to Cite

Lee, I., Kobayashi, K., Sun, H.Y., Takatani, S. and Zhong, L.G. (2007), Biomembrane mimetic polymer poly (2-methacryloyloxyethyl phosphorylcholine-co-n-butyl methacrylate) at the interface of polyurethane surfaces. J. Biomed. Mater. Res., 82A: 316–322. doi: 10.1002/jbm.a.30951

Author Information

  1. 1

    The Key Laboratory of Bioactive Materials and of Advanced Techniques & Fabrication For Weak-Light Nonlinear Photonics Materials, Nankai University, Tianjin 300071, People's Republic of China

  2. 2

    Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Chiyoda-Ku, Tokyo 101-0062, Japan

*The Key Laboratory of Bioactive Materials and of Advanced Techniques & Fabrication For Weak-Light Nonlinear Photonics Materials, Nankai University, Tianjin 300071, People's Republic of China

Publication History

  1. Issue published online: 14 JUN 2007
  2. Article first published online: 12 FEB 2007
  3. Manuscript Accepted: 8 JUN 2006
  4. Manuscript Revised: 18 MAY 2006
  5. Manuscript Received: 15 SEP 2005

Funded by

  • Ministry of Education, Science, Culture, and Sports, Japan

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Keywords:

  • PMB polymer;
  • polyurethanes (PU);
  • absorption kinetics;
  • atomic force microscopy (AFM);
  • water contact angle measurements

Abstract

Polyurethane (PU) is widely used to make artificial heart and blood vessel wells; however, its thrombogenicity in vivo is still in question. The biomembrane-mimetic and water-soluble polymers, poly (2-methacryloyloxyethyl phosphorylcholine-co-n-butyl methacrylate) (PMB), were used to modify polyurethane (PU) surfaces for improving their hemocompatibility. The morphologies of the PMB modified PU surfaces were examined by using atomic force microscopy and the parameters of the PMB absorption kinetics were extracted from dynamic water contact angle measurements. Two-phase domains, the hard and soft segment phases, were observed on the PU surfaces under the aqueous conditions. The absorbed PMB molecules formed the isolated layers first on the hydrophobic hard segments, and subsequently networked as the PMB concentration increased. The increments of PMB concentration led to the decrement of the effective molar activation (wetting) free energy ΔG. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2007

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