Robotic deposition of model hydroxyapatite scaffolds with multiple architectures and multiscale porosity for bone tissue engineering

  1. Jennifer G. Dellinger1,†,
  2. Joseph Cesarano III2,
  3. Russell D. Jamison1,*

Article first published online: 12 FEB 2007

DOI: 10.1002/jbm.a.31072

Issue

Journal of Biomedical Materials Research Part A

Journal of Biomedical Materials Research Part A

Volume 82A, Issue 2, pages 383–394, August 2007

Additional Information

How to Cite

Dellinger, J. G., Cesarano, J. and Jamison, R. D. (2007), Robotic deposition of model hydroxyapatite scaffolds with multiple architectures and multiscale porosity for bone tissue engineering. J. Biomed. Mater. Res., 82A: 383–394. doi: 10.1002/jbm.a.31072

Author Information

  1. 1

    Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, 1304 W. Green St. Urbana, Illinois 61821

  2. 2

    Sandia National Laboratories, P.O. Box 5800, Albuquerque, New Mexico 87185

  1. †

    Sandia National Laboratories, P.O. Box 5800, Albuquerque, NM 87185

*School of Engineering, Virginia Commonwealth University, 601 West Main Street, P.O. Box 843068, Richmond, VA 23284

Publication History

  1. Issue published online: 14 JUN 2007
  2. Article first published online: 12 FEB 2007
  3. Manuscript Accepted: 5 SEP 2006
  4. Manuscript Revised: 24 AUG 2006
  5. Manuscript Received: 5 JAN 2006

Funded by

  • Sandia National Laboratories, a multiprogram laboratory operated by Sandia Corporation, a Lockheed Martin Company, for the United States Department of Energy. Grant Number: DE-AC04-94AL85000
  • U.S. Department of Energy. Grant Number: DEFG02-91-ER45439
  • National Science Foundation Graduate Research Fellowship

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Keywords:

  • bone graft;
  • bone tissue engineering;
  • hydroxyapatite;
  • solid free form fabrication;
  • scaffold

Abstract

Model hydroxyapatite (HA) scaffolds with porosities spanning multiple length scales were fabricated by robocasting, a solid freeform fabrication technique based on the robotic deposition of colloidal pastes. Scaffolds of various architectures including periodic, radial, and superlattice structures were constructed. Macropores (100–600 μm) were designed by controlling the arrangement and spacing between rods of HA. Micropores (1–30 μm) and submicron pores (less than 1 μm) were produced within the rods by including polymer microsphere porogens in the HA pastes and by controlling the sintering of the scaffolds. These model scaffolds may be used to systematically study the effects of scaffold porosity on bone ingrowth processes both in vitro and in vivo. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2007

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