CaTiO3 coating on titanium for biomaterial application—Optimum thickness and tissue response

  1. Naofumi Ohtsu1,2,*,
  2. Kenji Sato2,
  3. Aya Yanagawa3,
  4. Kesami Saito2,
  5. Yoshio Imai3,
  6. Takao Kohgo3,
  7. Atsuro Yokoyama3,
  8. Katsuhiko Asami2,
  9. Takao Hanawa1

Article first published online: 5 FEB 2007

DOI: 10.1002/jbm.a.31136

Issue

Journal of Biomedical Materials Research Part A

Journal of Biomedical Materials Research Part A

Volume 82A, Issue 2, pages 304–315, August 2007

Additional Information

How to Cite

Ohtsu, N., Sato, K., Yanagawa, A., Saito, K., Imai, Y., Kohgo, T., Yokoyama, A., Asami, K. and Hanawa, T. (2007), CaTiO3 coating on titanium for biomaterial application—Optimum thickness and tissue response. J. Biomed. Mater. Res., 82A: 304–315. doi: 10.1002/jbm.a.31136

Author Information

  1. 1

    Department of Metallurgy, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo 101-0062, Japan

  2. 2

    Advance Research Center of Metallic Glasses, Institute for Material Research, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577, Japan

  3. 3

    Department of Oral Functional Science, Graduate School of Dental Medicine, Hokkaido University, Sapporo 060-8586, Japan

*Department of Metallurgy, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo 101-0062, Japan

Publication History

  1. Issue published online: 14 JUN 2007
  2. Article first published online: 5 FEB 2007
  3. Manuscript Accepted: 29 SEP 2006
  4. Manuscript Revised: 18 JUL 2006
  5. Manuscript Received: 17 JAN 2006

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Keywords:

  • biomaterials;
  • titanium;
  • CaTiO3 coating;
  • biocompatibility;
  • bone formation

Abstract

The objectives of this study were to determine the optimum thickness of a CaTiO3 film for biomaterial applications and to investigate the biocompatibility and bone formation of titanium with a CaTiO3 film. First, CaTiO3 films of 10, 20, 30, and 50 nm in thickness were deposited on titanium substrates using radiofrequency magnetron sputtering followed by annealing at 873 K in air for 7.2 ks. The optimum thickness of the CaTiO3 film for bone formation was determined by comparison with its performance regarding calcium phosphate formation in Hanks' balanced saline solution (HBSS). Regarding calcium phosphate formation, the performance of the specimen with a 50-nm-thick CaTiO3 film was superior to those of specimens with other thicknesses. A titanium prism with a CaTiO3 film of 50-nm in thickness was surgically inserted in both soft and hard rat tissues. The biocompatibility of CaTiO3-deposited titanium and bone formation on it was investigated by histological observations. A slight inflammatory reaction was observed around the titanium with the 50-nm-thick CaTiO3 film, while no severe response, such as degeneration and necrosis, was observed in either soft or hard rat tissue. New bone formation on the titanium plate with the CaTiO3 film was more active than that without the film. The 50-nm-thick CaTiO3 film has biocompatibility and can facilitate new bone formation in vivo, and, consequently, it is an excellent surface modification method for biomaterial applications. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2007

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