Novel tubular composite matrix for bone repair

  1. M.D. Kofron1,
  2. J.A. Cooper Jr.2,†,
  3. S.G. Kumbar3,
  4. C.T. Laurencin1,3,4,*

Article first published online: 12 FEB 2007

DOI: 10.1002/jbm.a.31148

Issue

Journal of Biomedical Materials Research Part A

Journal of Biomedical Materials Research Part A

Volume 82A, Issue 2, pages 415–425, August 2007

Additional Information

How to Cite

Kofron, M.D., Cooper, J.A., Kumbar, S.G. and Laurencin, C.T. (2007), Novel tubular composite matrix for bone repair. J. Biomed. Mater. Res., 82A: 415–425. doi: 10.1002/jbm.a.31148

Author Information

  1. 1

    Department of Biomedical Engineering, University of Virginia, PO Box 800759, Charlottesville, Virginia 22908

  2. 2

    School of Biomedical Engineering, Science, and Health Systems, Drexel University, 3141 Chestnut Street, Philadelphia, Pennsylvania 19104

  3. 3

    Department of Orthopaedic Surgery, University of Virginia Health System, PO Box 800159, Charlottesville, Virginia 22903

  4. 4

    Department of Chemical Engineering, University of Virginia, PO Box 400741, Charlottesville, Virginia 22903

  1. †

    Polymer Division, Biomaterials Group, National Institute of Standards and Technology, 100 Bureau Drive, Stop 8543, Gaithersburg, Maryland 20899-8543

*Department of Biomedical Engineering, University of Virginia, PO Box 800759, Charlottesville, Virginia 22908

Publication History

  1. Issue published online: 14 JUN 2007
  2. Article first published online: 12 FEB 2007
  3. Manuscript Accepted: 17 OCT 2006
  4. Manuscript Revised: 5 OCT 2006
  5. Manuscript Received: 19 JUL 2005

Funded by

  • NIH. Grant Numbers: AR052536, EB004051
  • NSF. Grant Numbers: BES-0503207, BES9553162, BES981782

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Keywords:

  • poly(lactide-co-glycolide);
  • hydroxyapatite;
  • tissue engineering;
  • tubular matrix;
  • bone

Abstract

Tissue engineering develops organ replacements to overcome the limitations associated with autografts and allografts. The work presented here details the development of biodegradable, porous, three-dimensional polymer–ceramic-sintered microsphere matrices to support bone regeneration. Poly(lactide-co-glycolide)/hydroxyapatite microspheres were formed using solvent evaporation technique. Individual microspheres were placed in a cylindrical mold and sintered at various temperatures. Scaffolds were characterized using scanning electron microscopy, mercury porosimetry, and mechanical testing in compression. After varying the temperature of sintering, a single temperature was selected and the time of sintering was varied. Mechanical testing indicated that as the sintering temperature or time was increased, the elastic modulus, compressive strength, maximum compressive load, and energy at failure significantly increased. Furthermore, increasing the sintering temperature or time resulted in a decreased porosity and the spherical morphology of the microspheres was lost as the microspheres blended together. To more closely mimic the bone marrow cavity observed in native bone tissue, tubular composite-sintered microsphere matrices were formed. These scaffolds demonstrated no statistically significant difference in compressive mechanical properties when compared with cylindrical composite-sintered microsphere matrices of the same dimension. One potential application for these scaffolds is bone regeneration. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2007

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