Macroporous condensed poly(tetra fluoro-ethylene). II. In vivo effect on adhesion formation and tissue integration

  1. Gabriela Voskerician1,*,
  2. Analiz Rodriguez2,
  3. Peter H. Gingras1

Article first published online: 12 FEB 2007

DOI: 10.1002/jbm.a.31155

Issue

Journal of Biomedical Materials Research Part A

Journal of Biomedical Materials Research Part A

Volume 82A, Issue 2, pages 426–435, August 2007

Additional Information

How to Cite

Voskerician, G., Rodriguez, A. and Gingras, P. H. (2007), Macroporous condensed poly(tetra fluoro-ethylene). II. In vivo effect on adhesion formation and tissue integration. J. Biomed. Mater. Res., 82A: 426–435. doi: 10.1002/jbm.a.31155

Author Information

  1. 1

    Proxy Biomedical Limited, Galway, Ireland

  2. 2

    Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106

*Proxy Biomedical Limited, Galway, Ireland

Publication History

  1. Issue published online: 14 JUN 2007
  2. Article first published online: 12 FEB 2007
  3. Manuscript Accepted: 31 OCT 2006
  4. Manuscript Revised: 19 OCT 2006
  5. Manuscript Received: 14 APR 2006

Funded by

  • Enterprise Ireland Research and Development Capability Grant. Grant Number: 132980

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Keywords:

  • in vivo hernia repair;
  • synthetic meshes;
  • intestinal adhesion;
  • tissue integration;
  • pull-out force

Abstract

This study investigated the in vivo correlation between construct parameters (surface area, pore size) and polymer chemistry in modulating mesh-intestinal adhesions and mesh-abdominal wall integration of condensed poly(tetra fluoro-ethylene) (cPTFE) in hernia repair. A defect created by excising a 2 cm circular section of the abdominal wall from a rat was repaired with cPTFE or either one of the following synthetic meshes: expanded PTFE (ePTFE), ePTFE + polypropylene (PP), PP or PP + oxidized regenerated cellulose (ORC). The intestinal adhesion and abdominal wall integration were studied quantitatively by measuring the pull-out force required to separate each mesh from the respective tissue at 1 and 3 months postimplantation. The hydrophobic, large pore meshes, such as cPTFE and ePTFE + PP led to reduced adhesions. Further, the presence of ORC contributed to reduction in adhesions of the more hydrophilic PP + ORC mesh. The large pore size, thinner meshes such as cPTFE and PP + ORC led to better tissue integration compared to the other meshes tested. Through hydrophobic chemistry, low profile, and increased pore size, cPTFE balances the rapid resolution of the inflammatory and wound healing response that resists adhesion formation, with efficient integration within the surrounding abdominal tissue. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2007

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