Biomedical modification of poly(L-lactide) by blending with lecithin

  1. N. Zhu1,
  2. F.Z. Cui1,*,
  3. K. Hu1,
  4. L. Zhu2

Article first published online: 12 FEB 2007

DOI: 10.1002/jbm.a.31159

Issue

Journal of Biomedical Materials Research Part A

Journal of Biomedical Materials Research Part A

Volume 82A, Issue 2, pages 455–461, August 2007

Additional Information

How to Cite

Zhu, N., Cui, F.Z., Hu, K. and Zhu, L. (2007), Biomedical modification of poly(L-lactide) by blending with lecithin. J. Biomed. Mater. Res., 82A: 455–461. doi: 10.1002/jbm.a.31159

Author Information

  1. 1

    Laboratory of Advanced Materials, Department of Materials Science and Engineering, Tsinghua University, Beijing 100084, People's Republic of China

  2. 2

    Institute of Cardiovascular Sciences, Health Science Center, Peking University, Beijing 100083, China

*Laboratory of Advanced Materials, Department of Materials Science and Engineering, Tsinghua University, Beijing 100084, People's Republic of China

Publication History

  1. Issue published online: 14 JUN 2007
  2. Article first published online: 12 FEB 2007
  3. Manuscript Accepted: 3 NOV 2006
  4. Manuscript Revised: 10 OCT 2006
  5. Manuscript Received: 27 AUG 2006

Funded by

  • National Key Basic research Program. Grant Number: 2005CB623905
  • NNSFC. Grant Number: 50143012
  • Tsinghua University

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Keywords:

  • poly(L-lactide);
  • lecithin;
  • film;
  • smooth muscle cells;
  • tissue engineering

Abstract

Lecithin was, for the first time, blended with PLLA to prepare scaffold material for tissue engineering applications in the present study. Solution blending was used to incorporate Lecithin (containing 0–10 wt %) with PLLA to enhance the blend films biocompatibility, hydrophilicity and toughness while maintaining mechanical strength of PLLA. The results of FTIR-ATR analysis indicated that the amino groups of lecitin existed in the films. DSC analysis indicated that Tg decreased with the increase of lecithin content in the blend films. The percentage elongation markedly increased with increase of lecithin content. The proliferation and viability of the vascular smooth muscle cell cultures on PLLA/Lecithin (containing 3–7 wt %) films were significantly enhanced compared to pure PLLA on tissue culture plates. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2007

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