Poly-L-lactic acid/hydroxyapatite hybrid membrane for bone tissue regeneration

  1. Gang Sui1,
  2. Xiaoping Yang1,*,
  3. Fang Mei2,
  4. Xiaoyang Hu2,
  5. Guoqiang Chen3,
  6. Xuliang Deng2,*,
  7. Seungkon Ryu4

Article first published online: 12 FEB 2007

DOI: 10.1002/jbm.a.31166

Issue

Journal of Biomedical Materials Research Part A

Journal of Biomedical Materials Research Part A

Volume 82A, Issue 2, pages 445–454, August 2007

Additional Information

How to Cite

Sui, G., Yang, X., Mei, F., Hu, X., Chen, G., Deng, X. and Ryu, S. (2007), Poly-L-lactic acid/hydroxyapatite hybrid membrane for bone tissue regeneration. J. Biomed. Mater. Res., 82A: 445–454. doi: 10.1002/jbm.a.31166

Author Information

  1. 1

    The Key Laboratory of Beijing City on Preparation and Processing of Novel Polymer, Beijing University of Chemical Technology, Beijing 100029, China

  2. 2

    School and Hospital of Stomatology, Peking University, Beijing 100081, China

  3. 3

    Department of Neurosurgery, Second Hospital of Tsinghua University, Beijing 100084, China

  4. 4

    Department of Chemical Engineering, Chungnam National University, Daejeon 305-764, Korea

*The Key Laboratory of Beijing City on Preparation and Processing of Novel Polymer, Beijing University of Chemical Technology, Beijing 100029, China

Publication History

  1. Issue published online: 14 JUN 2007
  2. Article first published online: 12 FEB 2007
  3. Manuscript Accepted: 3 NOV 2006
  4. Manuscript Revised: 8 OCT 2006
  5. Manuscript Received: 2 MAR 2006

Funded by

  • Nature Science Foundation of China. Grant Number: 30471907
  • Ministry of Science and Technology of China. Grant Number: 2004AA302G50
  • Tsinghua – YueYuen Medical Sciences Fund. Grant Number: 202400005.34

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Keywords:

  • hybrid membrane;
  • electrospinning;
  • bone tissue regeneration;
  • osteoblast cell;
  • cell adhesion

Abstract

Poly-L-lactic acid (PLLA)/hydroxyapatite (HA) hybrid membranes were fabricated via electrospinning of the PLLA/HA dispersion for use in bone tissue regeneration. The structural properties and morphologies of PLLA and PLLA/HA hybrid membrane were investigated by measuring the Brunauer-Emmett-Teller specific surface area, observations of SEM, and TEM. The dispersion and integrating of HA nanoparticles in the hybrid membrane were studied by energy dispersion X-ray analysis and FTIR. The mechanical properties of PLLA/HA membrane were also measured by tensile tests. For exploring biological behaviors of the hybrid membrane, in vitro degradation tests were carried out. The osteoblast cell (MG-63) was cultured in PLLA/HA hybrid membrane extract containing medium; the cell adhesion and growth capability were investigated by SEM observation and MTT assay. HA nanoparticles were not only dispersed in the PLLA but also reacted with the functional group of PLLA, resulting in strong surface bonding and high tensile strength of hybrid membrane. The cell adhesion and growth on the PLLA/HA hybrid membrane were far better than those on the pure PLLA membrane, which proves that the PLLA/HA hybrid membrane can be one of the promising biomaterials for bone tissue regeneration. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2007

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