Phagocyte responses to degradable polymers

  1. Wei-Wu Jiang1,
  2. Shih-Horng Su2,
  3. Robert C. Eberhart2,3,
  4. Liping Tang2,*

Article first published online: 12 FEB 2007

DOI: 10.1002/jbm.a.31175

Issue

Journal of Biomedical Materials Research Part A

Journal of Biomedical Materials Research Part A

Volume 82A, Issue 2, pages 492–497, August 2007

Additional Information

How to Cite

Jiang, W.-W., Su, S.-H., Eberhart, R. C. and Tang, L. (2007), Phagocyte responses to degradable polymers. J. Biomed. Mater. Res., 82A: 492–497. doi: 10.1002/jbm.a.31175

Author Information

  1. 1

    Department of Pediatrics, Baylor College of Medicine, Houston, Texas, 77030

  2. 2

    Joint Program in Biomedical Engineering, University of Texas at Arlington, PO Box 19138, Arlington, Texas 76019-0138 and University of Texas Southwestern Medical Center at Dallas, MC 9130, Dallas, Texas 75235-9130

  3. 3

    Department of Surgery, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hine Blvd, Dallas, Texas 75235-9130

*Joint Program in Biomedical Engineering, University of Texas at Arlington, PO Box 19138, Arlington, Texas 76019-0138 and University of Texas Southwestern Medical Center at Dallas, MC 9130, Dallas, Texas 75235-9130

Publication History

  1. Issue published online: 14 JUN 2007
  2. Article first published online: 12 FEB 2007
  3. Manuscript Accepted: 7 NOV 2006
  4. Manuscript Revised: 23 OCT 2006
  5. Manuscript Received: 17 JUL 2006

Funded by

  • NIH. Grant Number: R01 GM074021
  • American Heart Association (Established Investigator Award). Grant Number: 0245160N

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Keywords:

  • poly-L-lactic acid;
  • phagocyte;
  • inflammatory responses;
  • degradation;
  • superoxide;
  • degradable polymers;
  • inflammation;
  • neutrophils

Abstract

Although many biodegradable polymers, such as poly-L-lactic acid and poly-L-glycolic acid, are preferentially composed of biological residues normally present in the human body, implants made of these materials often trigger inflammatory and fibrotic responses. Unfortunately, the mechanisms involved in degradable material-mediated tissue responses remain largely unknown. Using animal implantation and cell culture system models, we found a strong correlation between the rate of material degradation and the degree of inflammatory response to material implants. Furthermore, we have identified that both water-soluble and water-insoluble degradation products are potent triggers of phagocyte activation, including at the least, superoxide production. These results support a new concept that slow degradation may improve the biocompatibility of degradable drug-releasing particles and tissue engineering scaffolds. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2007

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