Modified polycarbonate urethane: Synthesis, properties and biological investigation in vitro

  1. A. Szelest-Lewandowska1,*,
  2. B. Masiulanis1,
  3. M. Szymonowicz2,
  4. S. Pielka2,
  5. D. Paluch2

Article first published online: 25 MAY 2007

DOI: 10.1002/jbm.a.31357

Issue

Journal of Biomedical Materials Research Part A

Journal of Biomedical Materials Research Part A

Volume 82A, Issue 2, pages 509–520, August 2007

Additional Information

How to Cite

Szelest-Lewandowska, A., Masiulanis, B., Szymonowicz, M., Pielka, S. and Paluch, D. (2007), Modified polycarbonate urethane: Synthesis, properties and biological investigation in vitro. J. Biomed. Mater. Res., 82A: 509–520. doi: 10.1002/jbm.a.31357

Author Information

  1. 1

    Faculty of Chemistry, Department of Polymer Technology, Gdańsk University of Technology, 80-952 Gdańsk, Poland

  2. 2

    Department of Experimental Surgery and Biomaterials Research of Wrocław Medical University, 50-326 Wrocław, Poland

*Faculty of Chemistry, Department of Polymer Technology, Gdańsk University of Technology, 80-952 Gdańsk, Poland

Publication History

  1. Issue published online: 14 JUN 2007
  2. Article first published online: 25 MAY 2007
  3. Manuscript Accepted: 30 JAN 2007
  4. Manuscript Revised: 15 JAN 2007
  5. Manuscript Received: 4 JUL 2005

Funded by

  • State Committee for Scientific Research (KBN), Poland

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Keywords:

  • modified polycarbonate urethane;
  • physical properties;
  • resistance to sterilization;
  • cytotoxicity;
  • hemocompatibility

Abstract

A new polycarbonate urethane (PCU-I) was synthesized from aliphatic monomers, i.e. polyhexamethylene carbonate diol and 4,4′-methylene-bis cyclohexane diisocyanate, a mixture of low molecular diols, and castor oil (containing mainly the triglyceride of 12-hydroxyoleic acid). The second synthesized polymer (PCU-II) did not contain castor oil. Both PCUs had good tensile strength, i.e. 32.5 and 27.8 MPa for PCU-I and PCU-II, respectively. Modification by castor oil led to a decrease in glass transition temperature (Tg = −14°C for PCU-I and −6°C for PCU-II) and an increase in the softening temperature (135 and 125°C for PCU-I and PCU-II, respectively). Partial crosslinking of PCU-I increased the storage modulus of elasticity and provided better resistance to sterilization by ETO and γ radiation. Both PCUs displayed good stability when subjected to sterilization by hydrogen peroxide plasma. Neither PCU caused cytotoxic effect in mouse fibroblasts (3T3 Balb C). They also had no toxic effects on the morphotic components and did not influence changes in the hematologic parameters or plasmatic coagulation system of human blood. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res 2007

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