Closing capacity of segmental radius defects in rabbits

  1. Esther W.H. Bodde1,
  2. Paul H.M. Spauwen2,
  3. Antonios G. Mikos3,
  4. John A. Jansen1,*

Article first published online: 9 AUG 2007

DOI: 10.1002/jbm.a.31549

Issue

Journal of Biomedical Materials Research Part A

Journal of Biomedical Materials Research Part A

Volume 85A, Issue 1, pages 206–217, April 2008

Additional Information

How to Cite

Bodde, E. W., Spauwen, P. H., Mikos, A. G. and Jansen, J. A. (2008), Closing capacity of segmental radius defects in rabbits. Journal of Biomedical Materials Research Part A, 85A: 206–217. doi: 10.1002/jbm.a.31549

Author Information

  1. 1

    Department of Periodontology and Biomaterials, Radboud University, Nijmegen Medical Center, Nijmegen, P.O. Box 9101, 6500 HB, the Netherlands

  2. 2

    Department of Plastic and Reconstructive Surgery, Radboud University, Nijmegen Medical Center, Nijmegen, P.O. Box 9101, 6500 HB, the Netherlands

  3. 3

    Department of Bioengineering, Rice University, Houston, Texas 77251-1892

*Department of Periodontology and Biomaterials, Radboud University, Nijmegen Medical Center, Nijmegen, P.O. Box 9101, 6500 HB, the Netherlands

Publication History

  1. Issue published online: 21 FEB 2008
  2. Article first published online: 9 AUG 2007
  3. Manuscript Accepted: 28 MAY 2007
  4. Manuscript Revised: 8 MAY 2007
  5. Manuscript Received: 7 DEC 2006

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Keywords:

  • radius defect;
  • critical-size;
  • rabbit model;
  • PLGA;
  • microparticles

Abstract

In the research of synthetic bone graft substitutes, the relevance for bone regeneration can be confirmed in a critical-sized model. In this study the rabbit radial defect was investigated as an ingenious model of critical size, due to its defect immobilizing intact ulna. In addition, the influence of poly(DL-lactic-co-glycolic acid) (PLGA) on bone regeneration was determined. Sixteen, 4-month-old rabbits received bilateral segmental radial defects of 15 or 20 mm. The osteotomy ends were marked with small titanium pins. Half of the group received injected PLGA microparticle/carboxymethylcellulose implants. Implantation time was 12 weeks. Evaluation consisted of radiographs after surgery and sacrifice, microcomputed tomography and histology. The radiographs revealed that the created defects were significantly smaller after sacrifice. Further a number of radii showed fibrocartilaginous interposition. Both findings indicated instability of the created defect. All evaluation techniques revealed that 15 and 20 mm were not of critical size, as most defects were more or less regenerated. PLGA microparticles did not influence bone regeneration significantly. In conclusion, 15- and 20-mm radius defects in 4-month-old rabbits were not a suitable model for bone regeneration as these defects were neither critical size nor stable. PLGA-microparticle degradation did not influence bone regeneration. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res 2008

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