Hydroxyapatite nanoparticle loaded collagen fiber composites: Microarchitecture and nanoindentation study

  1. Andrei Stanishevsky1,*,
  2. Shafiul Chowdhury1,
  3. Peserai Chinoda2,
  4. Vinoy Thomas1

Article first published online: 27 NOV 2007

DOI: 10.1002/jbm.a.31657

Issue

Journal of Biomedical Materials Research Part A

Journal of Biomedical Materials Research Part A

Volume 86A, Issue 4, pages 873–882, 15 September 2008

Additional Information

How to Cite

Stanishevsky, A., Chowdhury, S., Chinoda, P. and Thomas, V. (2008), Hydroxyapatite nanoparticle loaded collagen fiber composites: Microarchitecture and nanoindentation study. Journal of Biomedical Materials Research Part A, 86A: 873–882. doi: 10.1002/jbm.a.31657

Author Information

  1. 1

    Department of Physics, University of Alabama at Birmingham, Birmingham, Alabama 35294

  2. 2

    Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, Alabama 35294

*Department of Physics, University of Alabama at Birmingham, Birmingham, Alabama 35294

Publication History

  1. Issue published online: 5 AUG 2008
  2. Article first published online: 27 NOV 2007
  3. Manuscript Accepted: 19 JUL 2007
  4. Manuscript Revised: 18 APR 2007
  5. Manuscript Received: 11 OCT 2005

Funded by

  • National Science Foundation. Grant Number: CMS-0555778

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Keywords:

  • hydroxyapatite;
  • nanoparticles;
  • collagen;
  • electrospinning;
  • nanoindentation

Abstract

Hydroxyapatite (HA) nanoparticle—collagen composite materials with various HA/collagen weight ratios were prepared from HA/collagen dispersions using the solution deposition and electrospinning with static or rotating collectors. The composites with nanoparticle HA to collagen weight ratio of 80:20 can be easily prepared in the solution deposition approach, whereas in the electrospun fibrous composites it was possible to reach a maximum HA/collagen weight ratio of 30:70 while maintaining a good fibrous structure. The structure, surface morphology, and nanoindentation properties of these nanoparticle HA/collagen composites with different microarchitectures were investigated. The values from 0.2 GPa to 20 GPa for nanoindentation Young's modulus and from 25 MPa to 500 MPa for hardness, were obtained depending on the fabrication technique, composition, and microarchitecture of the composites. It was observed that the nanoindentation Young's modulus and hardness of the HA/collagen composite materials seem to achieve maximum values for 45–60% HA content by weight. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2008

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