Effect of surface chemistry modification of functional gold nanoparticles on the drug accumulation of cancer cells

  1. Min Song1,
  2. Xuemei Wang1,*,
  3. Jingyuan Li1,
  4. Renyun Zhang1,
  5. Baoan Chen2,
  6. Degang Fu1

Article first published online: 7 DEC 2007

DOI: 10.1002/jbm.a.31692

Issue

Journal of Biomedical Materials Research Part A

Journal of Biomedical Materials Research Part A

Volume 86A, Issue 4, pages 942–946, 15 September 2008

Additional Information

How to Cite

Song, M., Wang, X., Li, J., Zhang, R., Chen, B. and Fu, D. (2008), Effect of surface chemistry modification of functional gold nanoparticles on the drug accumulation of cancer cells. Journal of Biomedical Materials Research Part A, 86A: 942–946. doi: 10.1002/jbm.a.31692

Author Information

  1. 1

    State Key Lab of Bioelectronics, Chien-Shiung Wu Laboratory, Southeast University, Nanjing 210096, China

  2. 2

    School of Clinic Medical, Southeast University, Nanjing 210096, China

*State Key Lab of Bioelectronics, Chien-Shiung Wu Laboratory, Southeast University, Nanjing 210096, China

Publication History

  1. Issue published online: 5 AUG 2008
  2. Article first published online: 7 DEC 2007
  3. Manuscript Accepted: 31 JUL 2007
  4. Manuscript Revised: 19 JUN 2007
  5. Manuscript Received: 11 MAR 2007

Funded by

  • National Natural Science Foundation of China. Grant Numbers: 20675014, 20535010, 60121101
  • Chinese Ministry of Education. Grant Number: 050462

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Keywords:

  • functional gold nanoparticles;
  • drug resistance;
  • leukemia;
  • drug-resistant and drug-sensitive leukemia K562 cells;
  • daunorubicin

Abstract

In this report, we have explored the possibility to facilitate the drug delivery efficiency for cancer cells through the surface chemistry modification of gold nanoparticles (AuNPs), where the functional AuNPs were synthesized by the ligand exchange reaction between triphenyl phosphide-stabilized precursor nanoparticles and mercaptopropionic acid. Our observations demonstrate that the combination of the anticancer drug daunorubicin with relevant AuNPs could be used as an efficient way to mark the cancer cells, which may afford the potential application for the early diagnosis of the respective cancers. Besides, the synergistic enhanced effect of the relevant gold nanoparticles on the drug uptake of target cancer cells could provide a new strategy to inhibit the multidrug resistance of the respective cancers. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res 86A: 942–946, 2008

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