Spray-dried lipid-hyaluronan-polymethacrylate microparticles for drug delivery in the peritoneum

  1. Yuliya A. Domnina1,
  2. Yoon Yeo2,3,
  3. Julie Y. Tse4,
  4. Evangelia Bellas4,
  5. Daniel S. Kohane5,*

Article first published online: 6 FEB 2008

DOI: 10.1002/jbm.a.31741

Issue

Journal of Biomedical Materials Research Part A

Journal of Biomedical Materials Research Part A

Volume 87A, Issue 3, pages 825–831, 1 December 2008

Additional Information

How to Cite

Domnina, Y. A., Yeo, Y., Tse, J. Y., Bellas, E. and Kohane, D. S. (2008), Spray-dried lipid-hyaluronan-polymethacrylate microparticles for drug delivery in the peritoneum. J. Biomed. Mater. Res., 87A: 825–831. doi: 10.1002/jbm.a.31741

Author Information

  1. 1

    Division of Pediatric Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114

  2. 2

    Department of Industrial and Physical Pharmacy, Purdue University, West Lafayette, Indiana 47907

  3. 3

    Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana 47907

  4. 4

    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139

  5. 5

    Laboratory for Biomaterials and Drug Delivery, Department of Anesthesiology, Division of Critical Care Medicine, Children's Hospital, Boston, Massachusetts 02115

*Laboratory for Biomaterials and Drug Delivery, Department of Anesthesiology, Division of Critical Care Medicine, Children's Hospital, Boston, Massachusetts 02115

Publication History

  1. Issue published online: 24 OCT 2008
  2. Article first published online: 6 FEB 2008
  3. Manuscript Accepted: 14 JUN 2007
  4. Manuscript Revised: 7 JUN 2007
  5. Manuscript Received: 11 MAR 2007

Funded by

  • DuPont-MIT Alliance
  • National Institutes of General Medical Studies. Grant Number: GM073626

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Keywords:

  • microparticles;
  • adhesion;
  • peritoneum;
  • phospholipid;
  • biocompatibility

Abstract

Application of controlled release technology to the peritoneum would allow for sustained drug levels. However, some polymeric systems either create adhesions, or rapidly exit the peritoneum; neither result is desirable. Here we have produced particles based on sphyngomyelin, a phospholipid that occurs naturally in the peritoneum, along with hyaluronic acid and the polymethacrylate Eudragit E100 (to modulate drug release). Particles with a low proportion of E100 (5% (w/w); “high SPM”) release albumin rapidly over 2 days, then more slowly; increasing the E100 to 20% (w/w; high “E100”) slowed drug release markedly. When injected in the murine peritoneum, high SPM particles were disseminated as free particles, without forming collections. There was a mild inflammatory response but no formation of adhesions. High E100 particles formed collections in all animals, with an intense inflammatory response. Even so, there were very few adhesions. These results suggest that microparticulate formulations can be produced that have acceptable drug-releasing properties and are suitable for use in the peritoneum from the standpoint of biocompatibility. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res 2008

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