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Hydrogels used for cell-based drug delivery

  1. John J. Schmidt1,2,
  2. Jon Rowley3,
  3. Hyun Joon Kong1,2,*

Article first published online: 6 OCT 2008

DOI: 10.1002/jbm.a.32287

Issue

Journal of Biomedical Materials Research Part A

Journal of Biomedical Materials Research Part A

Volume 87A, Issue 4, pages 1113–1122, 15 December 2008

Additional Information

How to Cite

Schmidt, J. J., Rowley, J. and Kong, H. J. (2008), Hydrogels used for cell-based drug delivery. J. Biomed. Mater. Res., 87A: 1113–1122. doi: 10.1002/jbm.a.32287

Author Information

  1. 1

    Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61822

  2. 2

    Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61822

  3. 3

    Cell Therapy Research and Development, Lonza Walkersville, Walkersville, Maryland 21793

*Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61822

Publication History

  1. Issue published online: 4 NOV 2008
  2. Article first published online: 6 OCT 2008
  3. Manuscript Accepted: 5 AUG 2008
  4. Manuscript Received: 23 JUN 2008

Funded by

  • America Heart Association. Grant Number: 0830468Z
  • UIUC

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Keywords:

  • therapeutic protein;
  • cell viability;
  • biocompatibility;
  • biomolecular transport;
  • stiffness

Abstract

Stem cells, progenitor cells, and lineage-committed cells are being considered as a new generation of drug depots for the sustained release of therapeutic biomolecules. Hydrogels are often used in conjunction with the therapeutic secreting cells to provide a physical barrier to protect the cells from hostile extrinsic factors. Although the hydrogels significantly improve the therapeutic efficacy of transplanted cells, there have been no successful products commercialized based on these technologies. Recently, biomaterials are increasingly designed to provide cells with both a physical barrier and an extracellular matrix to further improve the secretion of therapeutic proteins from cells. This review will discuss (1) the cell encapsulation process, (2) the immunogenicity of the encapsulating hydrogel, (3) the transport properties of the hydrogel, (4) the hydrogel mechanical properties, and will propose new strategies to improve the hydrogel and cell interaction for successful cell-based drug delivery strategies. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res 2008

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