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Improved blood compatibility of Mg-1.0Zn-1.0Ca alloy by micro-arc oxidation

Authors

  • Da-Wei Wang,

    1. Department of Orthopedics, First Affiliated Hospital of Harbin Medical University, 150001 Harbin, People's Republic of China
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    • *

      These authors contributed equally to this work.

  • Yang Cao,

    1. Department of Orthopedics, First Affiliated Hospital of Harbin Medical University, 150001 Harbin, People's Republic of China
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    • *

      These authors contributed equally to this work.

  • Hui Qiu,

    1. Department of Stomatology, First Affiliated Hospital of Harbin Medical University, 150001 Harbin, People's Republic of China
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  • Zheng-Gang Bi

    Corresponding author
    1. Department of Orthopedics, First Affiliated Hospital of Harbin Medical University, 150001 Harbin, People's Republic of China
    • Department of Orthopedics, First Affiliated Hospital of Harbin Medical University, 150001 Harbin, People's Republic of China
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Errata

This article is corrected by:

  1. Errata: Erratum: Improved blood compatibility of Mg-1.0Zn-1.0Ca alloy by micro-arc oxidation Volume 100A, Issue 10, 2861, Article first published online: 10 August 2012

  • How to cite this article: Wang D-W, Cao Y, Qiu H, Bi Z-G. Improved blood compatibility of Mg-1.0Zn-1.0Ca alloy by micro-arc oxidation. J Biomed Mater Res Part A 2011:99A:162–172.

Abstract

Magnesium and its alloys have been used in the recent development of lightweight, biodegradeable implant materials. However, the corrosion properties of magnesium limit its usefulness. In a previous study, a micro-arc oxidation (MAO) method was used to modify a Mg-1.0 wt % Zn-1.0 wt % Ca alloy surface, with the purpose of improving the corrosion resistance of Mg alloys. However, the blood compatibility of MAO-treated Mg alloy is unknown. Results of cytotoxicity assays with bone marrow-derived mesenchymal stem cells showed that extracts of MAO-treated alloy significantly decreased cytotoxicity compared to titanium alloy extract. Results of blood compatibility tests showed that the MAO group had a decreased hemolytic ratio (2.25%) compared to the untreated Mg alloy group (24.58%) (p < 0.001). The MAO group showed significantly shorter prothrombin and thrombin times and significantly longer activated partial thromboplastin time than the untreated Mg alloy group. Arachidonic acid- and adenosine diphosphate-induced platelet aggregations were significantly decreased by the untreated Mg alloy extract, and they were less affected by extract of MAO-treated Mg alloy. In conclusion, MAO-treated Mg-1.0 wt % Zn-1.0 wt % Ca alloy exhibits favorable blood compatibility characteristics and may be useful in the development of magnesium implant materials. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part A:, 2011.

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