Get access

Mechanical characterization and biocompatibility of a novel reinforced fascia patch for rotator cuff repair

Authors

  • Amit Aurora,

    1. Department of Biomedical Engineering and Orthopedic Research Center, Cleveland Clinic, Cleveland, Ohio
    2. Department of Chemical and Biomedical Engineering, Cleveland State University, Cleveland, Ohio
    Search for more papers by this author
  • Mena Mesiha,

    1. Department of Orthopedic Surgery, Orthopedic and Rheumatologic Institute, Cleveland Clinic, Cleveland, Ohio
    Search for more papers by this author
  • Carmela D. Tan,

    1. Department of Anatomic Pathology, Cleveland Clinic, Cleveland, Ohio
    Search for more papers by this author
  • Esteban Walker,

    1. Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio
    Search for more papers by this author
  • Sambit Sahoo,

    1. Department of Biomedical Engineering and Orthopedic Research Center, Cleveland Clinic, Cleveland, Ohio
    Search for more papers by this author
  • Joseph P. Iannotti,

    1. Department of Biomedical Engineering and Orthopedic Research Center, Cleveland Clinic, Cleveland, Ohio
    2. Department of Orthopedic Surgery, Orthopedic and Rheumatologic Institute, Cleveland Clinic, Cleveland, Ohio
    Search for more papers by this author
  • Jesse A. McCarron,

    1. Orthopedic Surgery Section, Department of VA Medical Center, Portland, Oregon
    Search for more papers by this author
  • Kathleen A. Derwin

    Corresponding author
    1. Department of Biomedical Engineering and Orthopedic Research Center, Cleveland Clinic, Cleveland, Ohio
    2. Department of Orthopedic Surgery, Orthopedic and Rheumatologic Institute, Cleveland Clinic, Cleveland, Ohio
    • Department of Biomedical Engineering and Orthopedic Research Center, Cleveland Clinic, Cleveland, Ohio
    Search for more papers by this author

  • The author, or one or more of the authors, has received or will receive remuneration or other prequisites for personal or professional use from a commercial or industrial agent in direct or indirect relationship to their authorship.

  • How to cite this article: Aurora A, Mesiha M, Tan CD, Walker E, Sahoo S, Iannotti JP, McCarron JA, Derwin KA. 2011. Mechanical characterization and biocompatibility of a novel reinforced fascia patch for rotator cuff repair. J Biomed Mater Res Part A 2011:99A:221-230.

Abstract

To provide mechanical augmentation for rotator cuff repair, it is necessary (though perhaps not sufficient) that scaffolds have tendon-like material and suture retention properties, be applied to the repair in a surgically appropriate manner, and maintain their mechanical properties for an acceptable period of time following surgery. While allograft fascia lata has material, structural, and biochemical properties similar to tendon tissue, its poor suture retention properties abrogates its potential as an augmentation device. The goal of this work was to design a novel reinforced fascia patch with suture retention and stiffness properties adequate to provide mechanical augmentation for rotator cuff repair. Fascia was reinforced by stitching with PLLA or PLLA/PGA polymer braids. Reinforced fascia patches had a maximum construct load greater than (or equal to) the suture retention properties of human rotator cuff tendon (∼250N) at time zero and after in vivo implantation for 12 weeks in a rat subcutaneous model. The patches were able to withstand the 2500 loading cycles projected for the early post-operative period. The patches also demonstrated biocompatibility with the host using a rat abdominal wall defect model. These studies suggest the potential use of reinforced fascia patches to provide mechanical augmentation, minimize tendon retraction and possibly reduce the incidence of rotator cuff repair failure. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part A:, 2011.

Ancillary