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A theoretical model to characterize the drug release behavior of drug-eluting stents with durable polymer matrix coating

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  • How to cite this article: Zhao HQ, Jayasinghe D, Hossainy S, Schwartz LB. 2012. A theoretical model to characterize the drug release behavior of drug-eluting stents with durable polymer matrix coating. J Biomed Mater Res Part A 2012:100A:120–124.

Abstract

The time-dependent local drug delivery from drug-eluting stents (DES) plays a critical role in reducing restenosis in intravascular stenting. To better understand the basic mechanism of drug release for certain polymer-drug-coated DES platforms, a cylindrical diffusion model was applied successfully to quantitatively describe the experimental drug release data of Dynalink-E in vitro and in vivo. The results showed that the profiles of Dynalink-E everolimus release could be controlled by such characteristic parameters as coating thickness and diffusion coefficient. The model could be used to quantitatively characterize the drug release profiles and IVIV correlations. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2012.

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