How to cite this article: Nivison-Smith L, Weiss AS. 2012. Alignment of human vascular smooth muscle cells on parallel electrospun synthetic elastin fibers. J Biomed Mater Res Part A 2012:100A:155–161.
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Alignment of human vascular smooth muscle cells on parallel electrospun synthetic elastin fibers†
Article first published online: 14 OCT 2011
DOI: 10.1002/jbm.a.33255
Copyright © 2011 Wiley Periodicals, Inc.
Issue
Journal of Biomedical Materials Research Part A
Volume 100A, Issue 1, pages 155–161, January 2012
Additional Information
How to Cite
Nivison-Smith, L. and Weiss, A. S. (2012), Alignment of human vascular smooth muscle cells on parallel electrospun synthetic elastin fibers. J. Biomed. Mater. Res., 100A: 155–161. doi: 10.1002/jbm.a.33255
- †
Publication History
- Issue published online: 21 NOV 2011
- Article first published online: 14 OCT 2011
- Manuscript Accepted: 6 JUN 2011
- Manuscript Revised: 2 JUN 2011
- Manuscript Received: 28 MAR 2011
Funded by
- Australian Research Council
- National Health and Medical Research Council
- Abstract
- Article
- References
- Cited By
Keywords:
- smooth muscle cells;
- alignment;
- parallel fibers;
- elastin;
- electrospinning
Abstract
We generated parallel elastic fibers from synthetic elastin (SE) as a model of the arterial media and assessed the alignment of smooth muscle cells (SMCs). SE utilized crosslinked electrospun human tropoelastin to form aligned fibers that mimicked the topography and elastin-rich content of the medial extracellular matrix. Bundled parallel fibers were anisotropically more elastic than randomly arranged scaffolds (111 ± 25 kPa vs. 265 ± 17 kPa) in the direction of the fibers. Aligned and random fiber scaffolds each supported SMC growth. Following attachment, SMCs proliferated longitudinally on the parallel fibers and expressed native α-smooth muscle actin. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2012.