IRAK-M in macrophages around septically and aseptically loosened hip implants

Authors

  • Yangchun Zhang,

    1. Department of Joint Surgery, Huangpu Joint Centre, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 518000, China
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  • Changhe Hou,

    1. Department of Joint Surgery, Huangpu Joint Centre, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 518000, China
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  • Shiming Yu,

    1. Department of Joint Surgery, Huangpu Joint Centre, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 518000, China
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  • Jianhong Xiao,

    1. Department of Hematology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 518000, China
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  • Ziji Zhang,

    1. Department of Joint Surgery, Huangpu Joint Centre, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 518000, China
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  • Qiyi Zhai,

    1. Department of Joint Surgery, Huangpu Joint Centre, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 518000, China
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  • Jianwei Chen,

    1. Institute of Orthopedics, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 518000, China
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  • Ziqing Li,

    1. Department of Joint Surgery, Huangpu Joint Centre, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 518000, China
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  • Xibao Zhang,

    1. Guang Zhou Institute of Dermatology, Guang Zhou 510095, China
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  • Matti Lehto,

    1. School of Medicine, University of Tampere, Tampere, Finland
    2. Department of Orthopedics, Tampere University Hospital, Tampere, Finland
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  • Yrjö T. Konttinen,

    Corresponding author
    1. Department of Medicine, Helsinki University Central Hospital, Biomedicum, Helsinki, Finland
    2. ORTON Orthopaedic Hospital of the ORTON Foundation, Helsinki, Finland
    3. COXA Hospital for Joint Replacement, Tampere, Finland
    • Department of Medicine, Helsinki University Central Hospital, Biomedicum, Helsinki, Finland
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  • Puyi Sheng

    Corresponding author
    1. Department of Joint Surgery, Huangpu Joint Centre, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 518000, China
    2. Institute of Orthopedics, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 518000, China
    • Department of Joint Surgery, Huangpu Joint Centre, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 518000, China
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  • How to cite this article: Zhang Y, Hou C, Yu S, Xiao J, Zhang Z, Zhai Q, Chen J, Li Z, Zhang X, Lehto M, Konttinen YT, Sheng P. 2012. IRAK-M in macrophages around septically and aseptically loosened hip implants. J Biomed Mater Res Part A 2012:100A:261–268.

Abstract

The most common long-term complication of joint arthroplasty is loosening, which is mediated by chronic inflammatory cytokines produced by macrophages stimulated by implant-derived debris and eventually bacterial components adherent to such debris. In this study, antiinflammatory interleukin-1 receptor-associated kinase-M (IRAK-M) was studied in macrophages in interface membranes in vivo using immunohistochemical staining and in titanium particle-stimulated macrophages in vitro using reverse transcriptase-polymerase chain reaction. Results show that the interface membranes of septically and aseptically loosened prosthesis express more IRAK-M protein than control membranes from osteoarthritic patient and that IRAK-M mRNA-levels increase upon particle stimulation. These findings suggest that, the upregulation of IRAK-M in macrophages is involved in the local immunosuppression around implants, and may contribute to septic and aseptic implant loosening. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2012.

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