How to cite this article: Wang B-Y, Fu S-Z, Ni P-Y, Peng J-R, Zheng L, Luo F, Liu H, Qian Z-Y. 2012. Electrospun polylactide/poly(ethylene glycol) hybrid fibrous scaffolds for tissue engineering. J Biomed Mater Res Part A 2012:100A:441-449.
Electrospun polylactide/poly(ethylene glycol) hybrid fibrous scaffolds for tissue engineering †
Article first published online: 21 NOV 2011
Copyright © 2011 Wiley Periodicals, Inc.
Journal of Biomedical Materials Research Part A
Volume 100A, Issue 2, pages 441–449, February 2012
How to Cite
Wang, B.-Y., Fu, S.-Z., Ni, P.-Y., Peng, J.-R., Zheng, L., Luo, F., Liu, H. and Qian, Z.-Y. (2012), Electrospun polylactide/poly(ethylene glycol) hybrid fibrous scaffolds for tissue engineering . J. Biomed. Mater. Res., 100A: 441–449. doi: 10.1002/jbm.a.33264
- Issue published online: 22 DEC 2011
- Article first published online: 21 NOV 2011
- Manuscript Accepted: 6 SEP 2011
- Manuscript Revised: 18 AUG 2011
- Manuscript Received: 27 JUN 2011
- National 863 project. Grant Number: 2007AA021902
- New Century Excellent Talents in University. Grant Number: NCET-08-0371
- tissue engineering;
- fibrous scaffold;
The biodegradable polylactide/poly(ethylene glycol) (PLA/PEG) hybrid membranes were fabricated via electrospinning of PLA/PEG solution. Their structures and properties were investigated by scanning electron microscopy, differential scanning calorimetry, and water contact angle. In vitro hydrolytic degradation showed that PEG content influenced the degradation rate of the PLA/PEG hybrid mats. The mechanical property was measured by tensile test and the result revealed that the addition of PEG had an obvious plasticization on PLA matrix. In-vitro biocompatibility was investigated by culturing cell on the scaffolds and MTT assay. The results indicated that the cell could attach and proliferate on the membranes, so confirmed that the PLA/PEG hybrid membrane had good biocompatibility, and it could be a promising biomaterial for tissue engineering applications. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2012.