How to cite this article: Chen M, Shao Z, Chen X. 2012. Paclitaxel/loaded silk fibroin nanospheres. J Biomed Mater Res Part A 2012:100A:203–210..
Paclitaxel-loaded silk fibroin nanospheres †
Article first published online: 23 OCT 2011
Copyright © 2011 Wiley Periodicals, Inc.
Journal of Biomedical Materials Research Part A
Volume 100A, Issue 1, pages 203–210, January 2012
How to Cite
Chen, M., Shao, Z. and Chen, X. (2012), Paclitaxel-loaded silk fibroin nanospheres . J. Biomed. Mater. Res., 100A: 203–210. doi: 10.1002/jbm.a.33265
- Issue published online: 21 NOV 2011
- Article first published online: 23 OCT 2011
- Manuscript Accepted: 6 SEP 2011
- Manuscript Revised: 26 AUG 2011
- Manuscript Received: 9 JUN 2011
- National Natural Science Foundation of China. Grant Numbers: 20974025, 10979022
- natural polymer;
- hydrophobic interaction;
- anti-cancer drug;
- lymphatic chemotherapy
Silk fibroin is a very promising biomedical material because of its renewability, nontoxicity, biocompatibility, and biodegradability. On the basis of a simple and mild method for the preparation of silk fibroin nanospheres with controllable size, the authors developed earlier, anti-cancer drug paclitaxel (PTX)-loaded silk fibroin nanospheres ranging from 270 to 520 nm were produced accordingly. The drug loading, encapsulation efficiency, and released property of PTX-loaded silk fibroin nanospheres are depended on the silk fibroin concentration and initial PTX-loading capacity. The maximum drug loading is about 6.9% and the release time of such a kind of nanospheres is over 9 days. The release time of PTX-loaded silk fibroin nanospheres can be as long as 2 weeks when the drug loading is about 3.0%. All these results imply that such a kind of biomacromolecule-based anti-cancer drug nanocarrier has a great potential for chemotherapy in clinical applications. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2012.