How to cite this article: Kim J-E, Lee E-J, Kim H-E, Koh Y-H, Jang J-H. 2012. The impact of immobilization of BMP-2 on PDO membrane for bone regeneration. J Biomed Mater Res Part A 2012:100A:1488–1493.
The impact of immobilization of BMP-2 on PDO membrane for bone regeneration†
Article first published online: 6 MAR 2012
Copyright © 2012 Wiley Periodicals, Inc.
Journal of Biomedical Materials Research Part A
Volume 100A, Issue 6, pages 1488–1493, June 2012
How to Cite
Kim, J.-E., Lee, E.-J., Kim, H.-E., Koh, Y.-H. and Jang, J.-H. (2012), The impact of immobilization of BMP-2 on PDO membrane for bone regeneration. J. Biomed. Mater. Res., 100A: 1488–1493. doi: 10.1002/jbm.a.34089
- Issue published online: 11 APR 2012
- Article first published online: 6 MAR 2012
- Manuscript Accepted: 22 DEC 2011
- Manuscript Revised: 23 NOV 2011
- Manuscript Received: 16 AUG 2011
- The Korea Healthcare technology R&D Project, Ministry of Health & Welfare, Republic of Korea. Grant Number: A110416
- Inha University Research Grant
- bone morphogenetic protein-2;
- in vitro;
Poly(dioxanone) (PDO) is colorless, crystalline, a biodegradable synthetic polymers that is used for biomedical applications, such as surgical sutures, cardiovascular applications, orthopedics, and plastic surgery. Recently, bone morphogenetic protein-2 (BMP-2) is widely used for bone tissue engineering. For the first time we report here on the in vitro performance of an electrospun PDO membrane immobilized with BMP-2. Immobilized BMP-2 on PDO membrane enhanced ALPase activity, the osteogenic differentiation gene expressions as well as cell attachment, except cell proliferation when compared to that of PDO membrane alone. These results suggest that PDO membrane with BMP-2 is helpful to promote bone healing and regeneration. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2012.