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Effects of microrough and hierarchical hybrid micro/nanorough surface implants on osseointegration in ovariectomized rats: A longitudinal in vivo microcomputed tomography evaluation

Authors

  • Yuan Gao,

    1. Department of Prosthodontics, School of Stomatology, The Fourth Military Medical University, 145 West Changle Road, Xi'an 710032, Shaanxi, People's Republic of China
    2. Department of Stomatology, PLA 263 Hospital, Beijing 101149, People's Republic of China
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    • These authors contributed equally to this work and should be regarded as co-first authors.

  • Yongfeng Li,

    1. Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University, 145 West Changle Road, Xi'an 710032, Shaanxi, People's Republic of China
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    • These authors contributed equally to this work and should be regarded as co-first authors.

  • Jianrui Xiao,

    1. Department of Stomatology, PLA 252 Hospital, Baoding 071000, Hebei, People's Republic of China
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  • Lixian Xu,

    1. Department of Anesthesiology, School of Stomatology, The Fourth Military Medical University, 145 West Changle Road, Xi'an 710032, Shaanxi, People's Republic of China
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  • Kaijin Hu,

    1. Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University, 145 West Changle Road, Xi'an 710032, Shaanxi, People's Republic of China
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  • Liang Kong

    Corresponding author
    1. Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University, 145 West Changle Road, Xi'an 710032, Shaanxi, People's Republic of China
    • Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University, 145 West Changle Road, Xi'an 710032, Shaanxi, People's Republic of China
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  • How to cite this article: Gao Y, Li Y, Xiao J, Xu L, Hu K, Kong L. 2012. Effects of microrough and hierarchical hybrid micro/nanorough surface implants on osseointegration in ovariectomized rats: A longitudinal in vivo microcomputed tomography evaluation. J Biomed Mater Res Part A 2012:100A:2159–2167.

Abstract

This study aimed to evaluate the effects of microrough and hierarchical hybrid micro/nanorough surface implants on osseointegration in ovariectomized rats at different time points. Implants with machined, microrough and hierarchical hybrid micro/nanorough surfaces were inserted into the distal femurs of ovariectomized Sprague-Dawley female rats. At weeks 0, 4, and 12 following implantation, in vivo microcomputed tomography (micro-CT) scanning was used to assess bone microarchitectural changes. After 12 weeks, all the rats were sacrificed, and the femurs with implants were harvested for histological analysis and pull-out test. For the Micro-CT analysis, the trabecular number and the bone volume ratio increased significantly in the microrough group (p < 0.01) and micro/nanorough group (p < 0.01) compared with the machined group. The trabecular separation decreased significantly in the micro/nanorough group (p < 0.01) compared with the other two groups. For the maximum pull-out forces and the bone–implant-contact analyses, significant statistical differences were found among the three groups, with the following sequence: micro/nanorough group > microrough group > machined group. The results indicate that the microrough and the hierarchical hybrid micro/nanorough surfaces of the implant can be beneficial to osseointegration under osteoporotic conditions, and the hierarchical hybrid micro/nanorough surface is more efficient. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2012.

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