A.H.T. conceived the hypothesis; A.H.T., M.M., and Y.S.-D. designed the experiments; A.H.T. produced the biocoated electrodes; A.H.T., R.H., and A.M. performed the electrode implantation; A.H.T performed the data analyses and wrote the manuscript; and all the authors participated in editing and finalizing the manuscript.
Bioactive anti-inflammatory coating for chronic neural electrodes†
Article first published online: 4 APR 2012
Copyright © 2012 Wiley Periodicals, Inc.
Journal of Biomedical Materials Research Part A
Volume 100A, Issue 7, pages 1854–1858, July 2012
How to Cite
Taub, A. H., Hogri, R., Magal, A., Mintz, M. and Shacham-Diamand, Y. (2012), Bioactive anti-inflammatory coating for chronic neural electrodes. J. Biomed. Mater. Res., 100A: 1854–1858. doi: 10.1002/jbm.a.34152
How to cite this article: Taub AH, Hogri R, Magal A, Mintz M, Shacham-Diamand Y. 2012. Bioactive anti-inflammatory coating for chronic neural electrodes. J Biomed Mater Res Part A 2012:100A:1854–1858.
- Issue published online: 24 MAY 2012
- Article first published online: 4 APR 2012
- Manuscript Accepted: 22 FEB 2012
- Manuscript Revised: 5 FEB 2012
- Manuscript Received: 18 DEC 2011
- European Community's Seventh Framework Program (FP7). Grant Number: 216809
- Converging Technologies – ISF. Grant Number: 1709/07
Vol. 102, Issue 1, 304, Article first published online: 28 OCT 2013
- glial scar;
- chronic electrode;
- interleukin-1 receptor antagonist;
- brain computer interface;
- deep brain stimulation
Chronic electrodes are widely used for brain degenerative and psychiatric daises such as Parkinson's diseases, major depression, and obsessive-compulsive disorder, and for neuronal prosthesis. Brain immune reaction to electrodes in the form of glial scar encapsulates the electrode and reduces the efficacy of deep brain stimulation and neuronal prosthesis. State-of-the-art strategies for improving brain–electrode interface use passive protein coating to “camouflage” the electrode from the immune system. In this study, we actively reduced the brain immune reaction to the chronic electrodes using immune suppressing protein, that is, interleukin (IL)-1 receptor antagonist. IL-1 receptor antagonist-coated electrodes and noncoated electrodes were chronically implanted in rats. An additional group of rats was chronically implanted with IL-1 receptor antagonist- and laminin-coated electrodes (as passive protein). Examination of glial scaring 1ne and 4 weeks after implantation indicated a significant reduction in the amount of glial scar in the vicinity of the IL-1 receptor antagonist-coated electrode in comparison to both noncoated electrode and laminin-coated electrodes. The results strongly suggest that active immune suppressing protein reduces the level of immune reaction to chronic electrodes already after 1 week after implantation and generates less immune reaction then passive protein coating. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2012.